Ro 363
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- CAS号:
- 74513-77-2
- 英文名:
- Ro 363
- 英文别名:
- Ro 363;4-(3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy)benzene-1,2-diol;1,2-Benzenediol, 4-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-
- 中文名:
- Ro 363
- 中文别名:
- 化合物 T16769
- CBNumber:
- CB41322217
- 分子式:
- C19H25NO6
- 分子量:
- 363.4
- MOL File:
- 74513-77-2.mol
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Ro 363性质、用途与生产工艺
Ro 363 是一种有效且高度选择性的 β1 肾上腺素受体 (β1-adrenoceptor) 激动剂。RO 363 是一种有效的正性肌力活化剂，并且是一种心血管调节剂，可降低舒张压并显着增加心肌收缩力。
Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses.
In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations.
In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane.
Ro 363
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74513-77-2, Ro 363 相关搜索:
- 化合物 T16769
- 74513-77-2
- 1,2-Benzenediol, 4-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-
- 4-(3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy)benzene-1,2-diol
- Ro 363