111374-21-1
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- CAS号:
- 111374-21-1
- 英文名:
- HSR 6071
- 英文别名:
- HSR 6071;HSR6071,HSR-6071;2-Pyrazinecarboxamide, 6-(1-pyrrolidinyl)-N-2H-tetrazol-5-yl-;N-(1H-Tetrazol-5-yl)-6-(1-pyrrolidinyl)pyrazine-2-carboxamide;6-(1-Pyrrolidinyl)-N-(1H-tetrazol-5-yl)pyrazine-2-carboxamide
- 中文名:
- 111374-21-1
- 中文别名:
- 化合物 T11581
- CBNumber:
- CB41369874
- 分子式:
- C10H12N8O
- 分子量:
- 260.26
- MOL File:
- 111374-21-1.mol
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111374-21-1化学性质
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熔点:
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288-294 °C (decomp)(Solv: dimethyl sulfoxide (67-68-5))
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密度:
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1.555±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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2.61±0.10(Predicted)
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111374-21-1性质、用途与生产工艺
HSR6071 是吡嗪甲酰胺衍生物，是一种具有口服活性的，有效的抗过敏剂。HSR6071 有效抑制大鼠模型的实验性哮喘。
The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea.
HSR-6071 inhibits the IgE-mediated histamine release with an IC
50
of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.
111374-21-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-U00133 | 111374-21-1
HSR6071 | 111374-21-1 | 1mg | 1590元 |
| 2024/04/30 | HY-U00133 | 111374-21-1
HSR6071 | 111374-21-1 | 5mg | 3500元 |
111374-21-1, 111374-21-1 相关搜索:
- C10H12N8O
- 化合物 T11581
- 111374-21-1
- HSR6071,HSR-6071
- 2-Pyrazinecarboxamide, 6-(1-pyrrolidinyl)-N-2H-tetrazol-5-yl-
- N-(1H-Tetrazol-5-yl)-6-(1-pyrrolidinyl)pyrazine-2-carboxamide
- 6-(1-Pyrrolidinyl)-N-(1H-tetrazol-5-yl)pyrazine-2-carboxamide
- HSR 6071