EXHERIN
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- CAS号:
- 1135237-88-5
- 英文名:
- Exherin (trifluoroacetate)
- 英文别名:
- ADH-1 trifluroacetate;ADH-1 TRIFLUOROACETATE;Exherin (trifluoroacetate);ADH 1,ADH1 trifluoroacetate,Inhibitor,ADH1,ADH-1,inhibit,ADH 1 trifluoroacetate
- 中文名:
- EXHERIN
- 中文别名:
- ADH-1三氟乙酸盐;化合物EXHERIN TRIFLUOROACETATE
- CBNumber:
- CB42735520
- 分子式:
- C24H35F3N8O8S2
- 分子量:
- 684.7087096
- MOL File:
- 1135237-88-5.mol
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EXHERIN化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:43.0(Max Conc. mg/mL);62.8(Max Conc. mM)
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EXHERIN性质、用途与生产工艺
ADH-1 trifluoroacetate是选择性和竞争性的N-钙粘蛋白拮抗剂,具有潜在抗肿瘤和抗血管生成活性。
ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.
ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.
EXHERIN
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 5mg | 1100元 |
2024/04/30 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 10mM * 1mLin DMSO | 1657元 |
1135237-88-5, EXHERIN 相关搜索:
- 活性氧
- 多肽
- 抑制剂
- 环肽
- ADH-1三氟乙酸盐
- 化合物EXHERIN TRIFLUOROACETATE
- 1135237-88-5
- ADH 1,ADH1 trifluoroacetate,Inhibitor,ADH1,ADH-1,inhibit,ADH 1 trifluoroacetate
- ADH-1 TRIFLUOROACETATE
- ADH-1 trifluroacetate
- Exherin (trifluoroacetate)