1825355-56-3
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- CAS号:
- 1825355-56-3
- 英文名:
- Ribocil-C
- 英文别名:
- Ribocil-C;RibocilC,Ribocil C;4(3H)-Pyrimidinone, 2-[(3S)-1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-
- 中文名:
- 1825355-56-3
- 中文别名:
- 化合物 T12722L
- CBNumber:
- CB43067020
- 分子式:
- C21H21N7OS
- 分子量:
- 419.5
- MOL File:
- 1825355-56-3.mol
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1825355-56-3化学性质
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沸点:
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672.0±65.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 24.6 mg/mL (58.64 mM)
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酸度系数(pKa):
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8.44±0.50(Predicted)
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1825355-56-3性质、用途与生产工艺
Ribocil-C是高度选择性的细菌核黄素核糖开关 (bacterial riboflavin riboswitches) 抑制剂。
Bacterial riboflavin riboswitches
Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of
de novo
riboflavin (RF, vitamin B2) biosynthesis in
Escherichia coli
. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for
Staphylococcus aureus
growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including
Escherichia coli
,
Pseudomonas aeruginosa
, and
Acinetobacter baumannii
, to inhibit
ribB
expression, RF synthesis, and consequently arrest bacterial growth.
Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log
10
[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed.
1825355-56-3
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19488A | 1825355-56-3
Ribocil-C | 1825355-56-3 | 5mg | 900元 |
| 2024/04/30 | HY-19488A | 1825355-56-3
Ribocil-C | 1825355-56-3 | 10mM * 1mLin DMSO | 990元 |
1825355-56-3, 1825355-56-3 相关搜索:
- 化合物 T12722L
- 1825355-56-3
- RibocilC,Ribocil C
- 4(3H)-Pyrimidinone, 2-[(3S)-1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-
- Ribocil-C