ABT-100
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- CAS号:
- 450839-40-4
- 英文名:
- ABT-100
- 英文别名:
- ABT-100;ABT-100
(ABT100);[1,1'-Biphenyl]-3-carbonitrile, 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4'-(trifluoromethoxy)-
- 中文名:
- ABT-100
- 中文别名:
- 化合物 T10223
- CBNumber:
- CB43070433
- 分子式:
- C27H19F3N4O3
- 分子量:
- 504.46
- MOL File:
- 450839-40-4.mol
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ABT-100化学性质
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沸点:
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722.0±60.0 °C(Predicted)
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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-20°C, protect from light
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酸度系数(pKa):
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12.15±0.29(Predicted)
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ABT-100性质、用途与生产工艺
ABT-100 是一种有效的，高选择性和口服活性的 farnesyltransferase 抑制剂。ABT-100 抑制细胞增殖 (对于 EJ-1，DLD-1，MDA-MB-231，HCT-116，MiaPaCa-2，PC-3 和 DU-145 细胞的 IC50 分别为 2.2 nM，3.8 nM，5.9 nM，6.9 nM，9.2 nM，70 nM 和 818 nM)，可增加细胞凋亡并减少血管生成。ABT-100 具有广谱抗肿瘤活性。
ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth.
Cell Proliferation Assay
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Cell Line:
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EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells
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Concentration:
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0.1-100 nM
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Incubation Time:
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7 days
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Result:
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Demonstrated dose-dependent growth inhibition of human cancer cell lines.
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ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice.
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Animal Model:
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C.B-17 scid male mice with EJ-1 cells
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Dosage:
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6.25 mg/kg/day, 12.5 mg/kg/day
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Administration:
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Subcutaneous injection; daily; for 21 days
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Result:
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Regressed EJ-1 tumors in C.B-17 scid male mice.
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ABT-100
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-119257 | ABT-100 | | 1 mg | 1000元 |
| 2024/01/25 | HY-119257 | ABT-100
ABT-100 | 450839-40-4 | 5mg | 3600元 |
450839-40-4, ABT-100 相关搜索:
- 抑制剂
- 化合物 T10223
- 450839-40-4
- [1,1'-Biphenyl]-3-carbonitrile, 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4'-(trifluoromethoxy)-
- ABT-100
(ABT100)
- ABT-100