1050480-30-2
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- CAS号:
- 1050480-30-2
- 英文名:
- PhiKan 083 hydrochloride
- 英文别名:
- PhiKan083 hydrochloride >=98% (HPLC);1-(9-Ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride
- 中文名:
- 1050480-30-2
- 中文别名:
- 化合物 T16523;PHIKAN 083,P53稳定剂;1-(9-乙基-9H-咔唑-3-基)-N-甲基甲胺盐酸盐
- CBNumber:
- CB43411342
- 分子式:
- C16H19ClN2
- 分子量:
- 274.79
- MOL File:
- 1050480-30-2.mol
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1050480-30-2化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 50 mM in water and to 100 mM in DMSO
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水溶解性:
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Water: 2 mg/mL (7.28 mM and warming)
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1050480-30-2性质、用途与生产工艺
PhiKan 083 hydrochloride 是一种咔唑衍生物，可以稳定 p53 的突变体 Y220C，Kd 值为 167 μM，在 Ln229 细胞中，相对亲和力 (Kd) 为 150 μM；PhiKan 083 可用于癌症研究。
Kd: 167 μM (p53-Y220C), 150 μM (p53
Y220C
, in Ln229 cells)
PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes
Y220C
(a
p53
mutant), with a
K
d
of 167 μM, shows a relative binding affinity (K
d
) of 150 μM for p53
Y220C
in Ln229 cells.
PhiKan 083 slows down its thermal denaturation rate.
PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells.
PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53
wt
, p53
Y220C
, p53
G245S
, p53
R282W
).
Cell Viability Assay
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Cell Line:
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Ln229, Ln229-p53-wt, Ln229-p53-Y220C, Ln229-p53-G245S, Ln229-p53-R282W cells
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Concentration:
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125 μM
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Incubation Time:
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48 hours
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Result:
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Caused ∼70 ± 5% reduction in cell viability of variants of Ln229 cells.
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1050480-30-2
上下游产品信息
上游原料
下游产品
1050480-30-2, 1050480-30-2 相关搜索:
- 药靶配体
- PHIKAN 083,P53稳定剂
- 1-(9-乙基-9H-咔唑-3-基)-N-甲基甲胺盐酸盐
- 化合物 T16523
- 1050480-30-2
- 1-(9-Ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride
- PhiKan083 hydrochloride >=98% (HPLC)