IAXO-102
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- CAS号:
- 1115270-63-7
- 英文名:
- IAXO-102
- 英文别名:
- IAXO-102;IAXO-102 (CD14/TLR4 Antagonist) (synthetic);Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside;α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-;IAXO102,IAXO 102,Toll-like Receptor (TLR),Inhibitor,IAXO-102,inhibit
- 中文名:
- IAXO-102
- 中文别名:
- 化合物IAXO-102;(2R,3R,4S,5R,6S)-2-(氨基甲基)-6-甲氧基-4,5-双(十四烷氧基)四氢-2H-吡喃-3-醇
- CBNumber:
- CB44927534
- 分子式:
- C35H71NO5
- 分子量:
- 585.96
- MOL File:
- 1115270-63-7.mol
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IAXO-102化学性质
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沸点:
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650.2±55.0 °C(Predicted)
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密度:
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0.96±0.1 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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Ethanol : 50 mg/mL (85.33 mM; Need ultrasonic)|DMSO : 5 mg/mL (8.53 mM; Need ultrasonic)
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形态:
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A solid
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酸度系数(pKa):
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13.00±0.70(Predicted)
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IAXO-102性质、用途与生产工艺
IAXO-102 是一种靶向MD-2和CD14共同受体的 TLR4 的拮抗剂。IAXO-102 可抑制 MAPK 和p65 NF-κB 磷酸化,并下调TLR4依赖性促炎蛋白的表达。IAXO-102 可抑制实验性腹主动脉瘤 (AAA) 的发展。
Target | Value |
TLR4
()
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MAPK
()
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NF-κB
()
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IAXO-102 (1-10 µM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells.
IAXO-102 (10 µM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC.
Western Blot Analysis
Cell Line:
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Human umbilical vein endothelial (HUVEC) cells
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Concentration:
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1-10 µM
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Incubation Time:
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Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour
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Result:
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Significantly inhibited LPS-stimulated MAPK/p65nF-ΚB phosphorylation.
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IAXO-102 (3 mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice.
Animal Model:
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Six-monthold
ApoE
−/−
/C57Bl6
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Dosage:
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3 mg/kg/day
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Administration:
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S.C. for 28 days
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Result:
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Significantly retarded Angiotensin II-induced increase in aortic diameter.
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IAXO-102
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | S0002 | IAXO-102 IAXO-102 | 1115270-63-7 | 2mg | 1490.74元 |
2024/04/30 | HY-125171 | IAXO-102 IAXO-102 | 1115270-63-7 | 5mg | 2630元 |
1115270-63-7, IAXO-102 相关搜索:
- 药靶配体
- C35H71NO5
- 化合物IAXO-102
- (2R,3R,4S,5R,6S)-2-(氨基甲基)-6-甲氧基-4,5-双(十四烷氧基)四氢-2H-吡喃-3-醇
- 1115270-63-7
- IAXO-102 (CD14/TLR4 Antagonist) (synthetic)
- IAXO102,IAXO 102,Toll-like Receptor (TLR),Inhibitor,IAXO-102,inhibit
- Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside
- α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-
- IAXO-102