DICHLOROPHENYL-ABA
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- CAS号:
- 18201-65-5
- 英文名:
- DICHLOROPHENYL-ABA
- 英文别名:
- Dichlorophenyl ABA,DichlorophenylABA;benzoic acid, 2-[(3,5-dichlorophenyl)amino]-
- 中文名:
- DICHLOROPHENYL-ABA
- 中文别名:
- 化合物 T15116
- CBNumber:
- CB4503413
- 分子式:
- C13H9Cl2NO2
- 分子量:
- 282.12
- MOL File:
- 18201-65-5.mol
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DICHLOROPHENYL-ABA化学性质
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熔点:
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245 °C
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沸点:
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420.8±45.0 °C(Predicted)
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密度:
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1.470±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ~18 mg/mL at ~60 °C
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形态:
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solid
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酸度系数(pKa):
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3.62±0.36(Predicted)
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颜色:
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white
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DICHLOROPHENYL-ABA性质、用途与生产工艺
Dichlorophenyl-ABA 是转甲状腺素蛋白 (TTR) 淀粉样蛋白原纤维形成的抑制剂，可抑制表达 TTR L55P 的细胞中 80％ 以上的聚集体形成。
Transthyretin (TTR) amyloid fibril formation
Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are.
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity.
DICHLOROPHENYL-ABA
上下游产品信息
上游原料
下游产品
18201-65-5, DICHLOROPHENYL-ABA 相关搜索:
- 化合物 T15116
- 18201-65-5
- Dichlorophenyl ABA,DichlorophenylABA
- benzoic acid, 2-[(3,5-dichlorophenyl)amino]-