NF-56-EJ40
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- CAS号:
- 2380230-73-7
- 英文名:
- NF-56-EJ40
- 英文别名:
- NF-56-EJ40;NF56EJ40,inhibit,NF-56-EJ-40,NF 56 EJ40,GPR91,SUCNR1,Inhibitor;2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid;2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid;Benzeneacetic acid, 2-[[[4'-[(4-methyl-1-piperazinyl)methyl][1,1'-biphenyl]-3-yl]carbonyl]amino]-
- 中文名:
- NF-56-EJ40
- 中文别名:
- 化合物 T12216;化合物NF-56-EJ40;2-(2-(4'-((4-甲基哌嗪-1-基)甲基)-[1,1'-联苯]-3-甲酰胺基)苯基)乙酸;2-(2-(4'-((4-甲基哌嗪-1-基)甲基)-[1,1'-联苯]-3-甲酰胺基)苯基)乙酸
- CBNumber:
- CB45848962
- 分子式:
- C27H29N3O3
- 分子量:
- 443.54
- MOL File:
- 2380230-73-7.mol
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NF-56-EJ40化学性质
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沸点:
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586.6±50.0 °C(Predicted)
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密度:
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1.237±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL (11.27 mM); Water: 4.55 mg/mL (10.26 mM; ultrasonic and adjust pH to 9 with NaOH)
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酸度系数(pKa):
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4.14±0.10(Predicted)
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NF-56-EJ40性质、用途与生产工艺
NF-56-EJ40 是一种有效,高亲和力和高度选择性的人 SUCNR1 (GPR91) 拮抗剂,IC50 为 25 nM,Ki 为 33.5 nM,对大鼠 SUCNR1 几乎没有活性。 NF-56-EJ40 对人源化大鼠 SUCNR1 具有高亲和力,Ki 值为 17.4 nM。
NF-56-EJ40 is bound deep inside the hydrophobic pocket, with the acid group coordinated by the hydroxyl groups of the conserved residues Y83
2.64
and Y30
1.39
on one side, and R281
7.39
on the other side. The conserved E18
1.27
is predicted to form an additional hydrogen bond to the piperazine ring of NF-56-EJ40. E22
1.31
and N274
7.32
in human SUCNR1 are replaced by K181.31 and K269
7.32
in rat SUCNR1. These two amino acid exchanges could prevent the binding of NF-56-EJ40 to rat SUCNR1 owing to steric hindrance. Radioligand-binding studies with human SUCNR1 showed partial agreement with our homology model: the Y30
1.39
F mutant of human SUCNR1, shows reduced binding of NF-56-EJ40. Similar effects are observed with the E18
1.27
K and E18
1.27
R mutants, probably owing to steric clashes of the Lys and Arg residues with NF-56-EJ40 and the loss of a hydrogen bond to its piperazine ring.
Human SUCNR1 residues are introduced into rat SUCNR1 to form the double mutant K18
1.31
E/K269
7.32
N (hereafter denoted humanized rat SUCNR1) (
K
i
of 17.4 nM and 33.5 nM for human and humanized rat SUCNR1, respectively). NF-56-EJ40 increases the thermal stability of both humanized rat SUCNR1 and human SUCNR1, but not that of rat SUCNR1.
NF-56-EJ40
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-130246 | NF-56-EJ40 | | 1 mg | 1136元 |
2024/04/30 | HY-130246 | NF-56-EJ40 NF-56-EJ40 | 2380230-73-7 | 5mg | 2500元 |
2380230-73-7, NF-56-EJ40 相关搜索:
- 2-(2-(4'-((4-甲基哌嗪-1-基)甲基)-[1,1'-联苯]-3-甲酰胺基)苯基)乙酸
- 2-(2-(4'-((4-甲基哌嗪-1-基)甲基)-[1,1'-联苯]-3-甲酰胺基)苯基)乙酸
- 化合物NF-56-EJ40
- 化合物 T12216
- 2380230-73-7
- 2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid
- 2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid
- Benzeneacetic acid, 2-[[[4'-[(4-methyl-1-piperazinyl)methyl][1,1'-biphenyl]-3-yl]carbonyl]amino]-
- NF56EJ40,inhibit,NF-56-EJ-40,NF 56 EJ40,GPR91,SUCNR1,Inhibitor
- NF-56-EJ40