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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
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- CAS号:
- 945260-14-0
- 英文名:
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- 英文别名:
- (S)-CGP52421;Midostaurin Impurity 3;Midostaurin Impurity 1;(S)-3-Hydroxy Midostaurin;P37.7 (CGP52421 Epimer 1);(S) 3 Hydroxy Midostaurin,(S)3Hydroxy Midostaurin;3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1);Benzamide, N-[(3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
- 中文名:
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- 中文别名:
- 米哚妥林杂质1;化合物 T12791
- CBNumber:
- CB45864995
- 分子式:
- C35H30N4O5
- 分子量:
- 586.64
- MOL File:
- Mol file
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)化学性质
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密度:
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1.53±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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12.23±0.70(Predicted)
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)性质、用途与生产工艺
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) 是一种有效的激酶抑制剂，对 VEGFR-2，TRK-A，FLT3 等 13 种激酶的 IC50 值为 <400 nM。(S)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的次要代谢产物。(S)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。
(S)-3-Hydroxy Midostaurin ((S)-CGP52421; compound 4) has IC
50
values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme.
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI
50
=63 nM), KIT D816V (GI
50
=320 nM), and FLT3-ITD (GI
50
=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive.
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
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945260-14-0, 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) 相关搜索:
CGP52421 Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- 3HydroxyMidostaurinEpimer2(CGP52421Epimer2) 米哚妥林
- 米哚妥林杂质1
- 化合物 T12791
- 945260-14-0
- (S) 3 Hydroxy Midostaurin,(S)3Hydroxy Midostaurin
- P37.7 (CGP52421 Epimer 1)
- Benzamide, N-[(3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
- Midostaurin Impurity 3
- Midostaurin Impurity 1
- (S)-CGP52421
- (S)-3-Hydroxy Midostaurin
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)