BO-264
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- CAS号:
- 2408648-20-2
- 英文名:
- BO-264
- 英文别名:
- BO-264;3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine;4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-;inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
- 中文名:
- BO-264
- 中文别名:
- 化合物BO-264;英文名称:BO-264;3-(4-甲氧基苯基)-N-(2-吗啉嘧啶-4-基)异恶唑-5-胺
- CBNumber:
- CB46199294
- 分子式:
- C18H19N5O3
- 分子量:
- 353.38
- MOL File:
- 2408648-20-2.mol
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BO-264化学性质
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沸点:
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627.9±65.0 °C(Predicted)
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密度:
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1.306±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (>25 mg/ml)
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形态:
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solid
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酸度系数(pKa):
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6.69±0.10(Predicted)
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颜色:
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Off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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BO-264性质、用途与生产工艺
BO-264 是一种有效的 transforming acidic coiled-coil 3 (TACC3) 的口服抑制剂，IC50值为188 nM，Kd值为1.5 nM。BO-264 可特异性地阻断 FGFR3-TACC3 融合蛋白的功能。BO-264 可诱导SAC依赖的有丝分裂阻滞、凋亡和具有抗肿瘤活性的DNA损伤。
| Target | Value |
FGFR3
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TACC3
(Cell-free assay)
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1.5 nM(Kd)
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TACC3
(Cell-free assay)
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188 nM
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BO-264
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135960 | BO-264 | | 1 mg | 360元 |
| 2024/04/30 | HY-135960 | BO-264 | | 5 mg | 900元 |
2408648-20-2, BO-264 相关搜索:
- 药靶配体
- 3-(4-甲氧基苯基)-N-(2-吗啉嘧啶-4-基)异恶唑-5-胺
- 化合物BO-264
- 英文名称:BO-264
- 2408648-20-2
- inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
- 3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine
- 4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-
- BO-264