RISARESTAT
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- CAS号:
- 79714-31-1
- 英文名:
- CT 112
- 英文别名:
- Risarestat;RISARESTAT (CT-112);CT 112 (reductase inhibitor);5-(3-Ethoxy-4-pentoxyphenyl)thiazolidine-2,4-dione;5-(3-Ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione;5-[3-Ethoxy-4-(pentyloxy)phenyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[3-ethoxy-4-(pentyloxy)phenyl]-
- 中文名:
- RISARESTAT
- 中文别名:
- 化合物 T16756
- CBNumber:
- CB51334327
- 分子式:
- C16H21NO4S
- 分子量:
- 323.41
- MOL File:
- 79714-31-1.mol
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RISARESTAT化学性质
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沸点:
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485.9±45.0 °C(Predicted)
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密度:
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1.189±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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5.91±0.50(Predicted)
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RISARESTAT性质、用途与生产工艺
Risarestat (CT-112)是一种醛糖还原酶抑制剂,开发用于糖尿病并发症的研究。
Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution. Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns
2
. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm
2
. Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks.
RISARESTAT
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-16433 | Risarestat | | 1 mg | 2000元 |
2024/04/30 | HY-16433 | RISARESTAT Risarestat | 79714-31-1 | 5mg | 5000元 |
79714-31-1, RISARESTAT 相关搜索:
- 化合物 T16756
- 79714-31-1
- 2,4-Thiazolidinedione, 5-[3-ethoxy-4-(pentyloxy)phenyl]-
- RISARESTAT (CT-112)
- CT 112 (reductase inhibitor)
- Risarestat
- 5-[3-Ethoxy-4-(pentyloxy)phenyl]-2,4-thiazolidinedione
- 5-(3-Ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione
- 5-(3-Ethoxy-4-pentoxyphenyl)thiazolidine-2,4-dione