4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE
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- CAS号:
- 5465-86-1
- 英文名:
- 4-Methyl-2-(1-piperidinyl)-quinoline
- 英文别名:
- ML 204;NSC 25850;ML-204;ML204;4-Methyl-2-(1-piperidinyl)-quinoline;4-methyl-2-(piperidin-1-yl)quinoline;Quinoline, 4-methyl-2-(1-piperidinyl)-;Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
- 中文名:
- 4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE
- 中文别名:
- 化合物ML204;4-甲基-2-(1-哌啶基)喹啉
- CBNumber:
- CB52695379
- 分子式:
- C15H18N2
- 分子量:
- 226.32
- MOL File:
- 5465-86-1.mol
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4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE化学性质
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熔点:
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72-73 °C
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沸点:
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177-180 °C(Press: 4.5 Torr)
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密度:
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1.102±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble5mg/mL at warmed (clear solution)
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形态:
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powder
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酸度系数(pKa):
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7.34±0.61(Predicted)
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颜色:
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white to beige
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4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE性质、用途与生产工艺
ML204是新型的、有效的、选择性的TRPC4抑制剂。在胞内钙离子荧光分析试验中，IC50为1 μM。在全细胞电压钳实验中，IC50约为3 μM。ML204对TRPC通道的选择性远高于对其他TRP通道和非TRP通道的选择性。
ML204抑制TRPC4β介导的胞内钙离子上升，IC50为0.96 μM，其选择性是对毒蕈碱型受体耦合的TPRC6通道的19倍。ML204对TPRC4β的抑制不依赖于GPCR的激活。选择性实验表明，10-20 μM ML204对TRPV1, TRPV3, TRPA1, TRPM8和KCNQ2和小鼠背根神经节神经元中的电压依赖性钠离子通道、钾离子通道和钙离子通道没有明显抑制作用。ML204可抑制由G
i/o
或G
q/11
刺激诱导的TRPC4β活性
ML204 (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.
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Animal Model:
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Nonfasted male C57BL/6 (2-3 months)
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Dosage:
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1 mg/kg
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Administration:
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Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)
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Result:
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Induced mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
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4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12949 | ML204 | | 1 mg | 250元 |
| 2024/04/30 | HY-12949 | 4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE
ML204 | 5465-86-1 | 5mg | 500元 |
4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE
生产厂家
5465-86-1, 4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE 相关搜索:
- Aromatics, Heterocycles, Inhibitors
- Inhibitors
- 合成有机化合物配体
- 生物化工
- 小分子抑制剂
- 小分子抑制剂，天然产物
- 5485-86-1
- 化合物ML204
- 4-甲基-2-(1-哌啶基)喹啉
- 5465-86-1
- Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
- Quinoline, 4-methyl-2-(1-piperidinyl)-
- 4-methyl-2-(piperidin-1-yl)quinoline
- ML-204;ML204
- NSC 25850
- ML 204
- 4-Methyl-2-(1-piperidinyl)-quinoline