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网站主页 >> CAS数据库列表 >> sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate

生物活性 靶点 体外研究 体内研究

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate, 496807-11-5, 结构式
sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
CAS号:
496807-11-5
英文名:
sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
英文别名:
Beraprost impurity 27;Beraprost Impurity 10 Sodium Salt;Beraprost Sodium (Mixture of Diastereomers);Beraprost sodium (Relative stereochemistry);sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
中文名:
sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
中文别名:
贝前列素杂质27;贝前列素杂质10 钠盐;(RAC)-贝拉前列素钠;贝前列素钠(非对映体混合物);贝前列素钠盐(非对映异构体的混合物);贝拉前列素钠盐(非对映异构体混合物)
CBNumber:
CB53400703
分子式:
C24H31NaO5
分子量:
422.5
MOL File:
496807-11-5.mol

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate化学性质

储存条件:
Store at -20°C
溶解度:
DMSO: 250 mg/mL (594.57 mM)
安全信息

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate性质、用途与生产工艺

生物活性

Beraprost sodium 是一种前列环素类似物，是一种稳定且具有口服活性的 PGI2 前药。Beraprost sodium 是有效的血管扩张剂 (vasodilator)，通过扩张肾血管，改善微循环而具有研究肺动脉高压的潜力。

靶点

prodrug of PGI2; Vasodilator

体外研究

Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity. Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment let VE-cadherin at regions of cell–cell contact becomes more abundant and the morphology of endothelial cells tends to be normal compared with those cultured under hypoxia conditions.

体内研究

Beraprost sodium (oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days) can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis.

Animal Model: 6-8-week-old C57Bl/6J Male Mice
Dosage: 0.6 mg/kg
Administration: Oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days
Result: Mitigated the development of renal interstitial fibrosis.

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate 上下游产品信息

上游原料

下游产品

sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate 生产厂家

全球有 17家供应商   sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate国内生产厂家
供应商联系电话电子邮件国家产品数优势度
TargetMol中国（陶术生物） 021-021-33632979 15002134094 marketing@targetmol.com 中国 7854 58
上海柯维化学技术有限公司 021-64609169 18901607656 greensnown@163.com 中国 9911 50
广州市桐晖药业有限公司 020-61855200 13326451905 2881290884@qq.com 中国 7524 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
南京望知星医药科技有限公司 15850510341 shiqingran@wzxchem.com 中国 3567 58
上海弘渠生物医药科技有限公司 88888888888 hongquchem@qq.com 中国 5132 58
广州佳途科技股份有限公司 020-81960175-877 18933936954 tianwen.zhan@cato-chem.com 中国 7722 58
南京华诺生物医药科技有限公司 18913906212 2885426135@qq.com 中国 6580 58
山东默派生物科技有限公司 13053322091 13053322091 admin@mopaikeji.com 中国 10974 58
湖北清北云研医药科技有限责任公司 18162595016 3287908757@qq.com 中国 9887 58
广州市震霖医药科技有限公司 18102736234 18102736234 2208093734@qq.com 中国 6348 58
Aladdin Scientific +1-+1(833)-552-7181 sales@aladdinsci.com 美国 52927 58
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com 中国 11013 58
China National Standard Pharmaceutical Corporation Limited +8615391658522 overseasales@yongstandards.com 中国 11927 58
 

496807-11-5, sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate 相关搜索:

贝拉前列素杂质4 BERAPROSTMETHYLESTER 贝前列素钠 贝拉前列素杂质3 BERAPROSTIMPURITY2 BERAPROST(8S,9S,16S)ISOMER BERAPROST15-RISOMERSODIUMSALT BERAPROST(8S,9S,16R)ISOMER 贝前列素杂质1
  • 贝前列素杂质
  • 贝前列素钠(非对映体混合物)
  • 贝前列素杂质10 钠盐
  • 贝前列素杂质27
  • 贝前列素钠盐(非对映异构体的混合物)
  • (RAC)-贝拉前列素钠
  • 贝拉前列素钠盐(非对映异构体混合物)
  • 496807-11-5
  • Beraprost Sodium (Mixture of Diastereomers)
  • Beraprost impurity 27
  • Beraprost Impurity 10 Sodium Salt
  • Beraprost sodium (Relative stereochemistry)
  • sodium:4-[(1R,2R,3aS,8bS)-2-hydroxy-1-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate
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