雷洛昔芬-4' -葡萄糖醛酸苷
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- CAS号:
- 182507-22-8
- 英文名:
- Raloxifene 4'-glucuronide
- 英文别名:
- Raloxifene Impurity 7;RALOXIFENE-4-GLUCURONIDE;Raloxifene 4'-glucuronide;Raloxifene 4'-D-glucuronide;RALOXIFENE-D4-4'-GLUCURONIDE;Raloxifene p-β-D-Glucuronide;Raloxifene 4'-O-β-D-glucuronide;Raloxifene 4'-O-β-D-glucuronide;Raloxifene-4'-glucuronide lithiuM salt;Raloxifene-4'-D-glucuronide lithium salt
- 中文名:
- 雷洛昔芬-4' -葡萄糖醛酸苷
- 中文别名:
- 普伐他汀-[D9]铵盐;雷洛昔芬-4'-葡糖苷酸;雷洛昔芬-4' -葡萄糖醛酸苷;雷洛昔芬-4'-葡萄糖醛酸苷锂盐;雷洛昔芬-4-葡糖苷酸[干冰运输];雷洛昔芬4'-O-Β-D-葡糖醛酸;雷洛昔芬-D4-4' -葡萄糖醛酸苷;雷洛昔芬4'-O-Β-D-葡萄糖醛酸;雷洛昔芬 4'-O-Β-D-葡萄糖苷酸;雷洛昔芬-4-葡萄糖醛酸苷(雷洛昔芬杂质24)
- CBNumber:
- CB5433405
- 分子式:
- C34H35NO10S
- 分子量:
- 649.71
- MOL File:
- 182507-22-8.mol
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雷洛昔芬-4' -葡萄糖醛酸苷化学性质
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熔点:
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209-213°C
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沸点:
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949.6±65.0 °C(Predicted)
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密度:
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1.444±0.06 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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2.76±0.70(Predicted)
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颜色:
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Yellow
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稳定性:
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Hygroscopic
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雷洛昔芬-4' -葡萄糖醛酸苷性质、用途与生产工艺
Raloxifene 4'-glucuronide 是 Raloxifene 的主要代谢产物。Raloxifene 4'-glucuronide 的形成主要由 UGT1A10 和 UGT1A8 介导，以 IC50 为 370 μM 与 estrogen receptor 结合。Raloxifene 是选择性雌激素受体调节剂。 Raloxifene 在纳摩尔浓度激活 TGFβ3 启动子为完全激动剂，并抑制含雌激素反应元件的卵黄蛋白原启动子的表达。
IC50: 370 μM (Estrogen receptor)
Expressed UGT1A8 catalyzes Raloxifene 4'-glucuronide with an apparent K
m
of 59 μM and a V
max
of 2.0 nmol/min/mg. Based on rates of Raloxifene glucuronidation and known extrahepatic expression, UGT1A8 and 1A10 appear to be primary contributors to Raloxifene glucuronidation in human jejunum microsomes. For human liver microsomes, the variability of Raloxifene 4'-glucuronide formation is 4-fold. Treatment of expressed UGTs with alamethicin results in minor increases in enzyme activity, whereas in human intestinal microsomes, maximal increases of 9-fold for the Raloxifene 4'-glucuronide are observed. Intrinsic clearance values in intestinal microsomes are 95 μl/min/mg for the Raloxifene 4'-glucuronide.
雷洛昔芬-4' -葡萄糖醛酸苷
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182507-22-8, 雷洛昔芬-4' -葡萄糖醛酸苷 相关搜索:
- Isotope Labeled Compounds
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Glucuronides
- Isotope Labelled Compounds
- 标准品
- C34H34LiNO10S
- C34H35LiNO10S
- C34H31NO10SD4
- C34H31D4NO10S
- C34H35NO10S
- 雷洛昔芬4'-O-Β-D-葡糖醛酸
- 雷洛昔芬 4'-O-Β-D-葡萄糖苷酸
- 雷洛昔芬-4-葡萄糖醛酸苷(雷洛昔芬杂质24)
- 雷洛昔芬4'-O-Β-D-葡萄糖醛酸
- 3,4,5-三羟基-6-[4-[6-羟基-3-[4-[2-(1-哌啶基)乙氧基]苯甲酰基]苯并噻吩-2-基]苯氧基]四氢吡喃-2-羧酸
- 普伐他汀-[D9]铵盐
- 雷洛昔芬-4-葡糖苷酸[干冰运输]
- 4-[6-羟基-3-3-[4-[2-(1-哌啶基)乙氧基]苯甲酰基]苯并[b]噻吩-2-基]苯基 β-D-吡喃葡萄糖醛酸
- 雷洛昔芬-4'-葡糖苷酸
- 雷洛昔芬-D4-4' -葡萄糖醛酸苷
- 雷洛昔芬-4'-葡萄糖醛酸苷锂盐
- 雷洛昔芬-4' -葡萄糖醛酸苷
- 182507-22-8
- Raloxifene 4'-O-β-D-glucuronide
- Raloxifene 4'-glucuronide
- 6-Hydroxy-4'-tert-butyldimethylsylyl Raloxifene-d4
- β-D-Glucopyranosiduronic acid, 4-[6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl
- Raloxifene 4-GlucuronideQ: What is
Raloxifene 4-Glucuronide Q: What is the CAS Number of
Raloxifene 4-Glucuronide Q: What is the storage condition of
Raloxifene 4-Glucuronide Q: What are the applications of
Raloxifene 4-Glucuronide
- Raloxifene 4'-O-β-D-glucuronide
- β-D-Glucopyranosiduronic acid, 4-[6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl
- Raloxifene p-β-D-Glucuronide
- (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[6-hydroxy-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-2-yl]phenoxy]oxane-2-carboxylic acid
- Raloxifene Impurity 7
- Raloxifene-d4-4'-glucuronide lithiuM salt
- Raloxifene-4'-glucuronide lithiuM salt
- Raloxifene 4'-D-glucuronide
- Raloxifene-4'-D-glucuronide lithium salt
- (4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy-D4]benzoyl]benzo[b]thien-2-yl]phenyl-D-glucopyranosiduronic acid)
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy-d4]benzoyl]benzo[b]thien-2-yl]phenyl-b-D-glucopyranosiduronic Acid
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl-b-D-glucopyranosiduronic Acid
- 4-[6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl-D-glucopyranosiduronicacid
- RALOXIFENE-4-GLUCURONIDE
- RALOXIFENE-D4-4'-GLUCURONIDE