ENDOVION
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- CAS号:
- 265646-85-3
- 英文名:
- Endovion
- 英文别名:
- NS3728;Endovion;NS3728 >=98% (HPLC);Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
- 中文名:
- ENDOVION
- 中文别名:
- 化合物ENDOVION;1-(3,5-双(三氟甲基)苯基)-3-(4-溴-2-(2H-四唑-5-基)苯基)脲
- CBNumber:
- CB55419734
- 分子式:
- C16H9BrF6N6O
- 分子量:
- 495.18
- MOL File:
- 265646-85-3.mol
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ENDOVION化学性质
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密度:
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1.791±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 100 mM in DMSO and to 50 mM in ethanol
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酸度系数(pKa):
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3.95±0.10(Predicted)
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水溶解性:
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Water : < 0.1 mg/mL (insoluble)
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ENDOVION性质、用途与生产工艺
Endovion (NS3728) 是一种阴离子通道抑制剂 (如氯离子通道)，也是特异性的 VRAC/VSOAC 阻断剂。Endovion (NS3728) 还是一种 ANO1 抑制剂。
Chloride channel, VRAC/VSOAC.
ANO1.
Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, e.g., expression of p21
Waf1/Cip1
, Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.
Western Blot Analysis
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Cell Line:
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Wild-type, resistant, and transiently transfected A2780 cells.
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Concentration:
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10-100 μM.
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Incubation Time:
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18 or 4.5 h.
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Result:
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Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells.
Resulted in an increased LRRC8A protein expression.
Significantly reduceed p53 and
p21Waf1/Cip1
protein level in A2780WT cells.
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Cell Proliferation Assay
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Cell Line:
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Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines.
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Concentration:
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10 μM.
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Incubation Time:
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24 h.
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Result:
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Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV.
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ENDOVION
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-105917 | ENDOVION
Endovion | 265646-85-3 | 5mg | 800元 |
| 2024/04/30 | HY-105917 | ENDOVION
Endovion | 265646-85-3 | 10mM * 1mLin DMSO | 872元 |
265646-85-3, ENDOVION 相关搜索:
- C16H9BrF6N6O
- CHBrFNO
- 化合物ENDOVION
- 1-(3,5-双(三氟甲基)苯基)-3-(4-溴-2-(2H-四唑-5-基)苯基)脲
- 265646-85-3
- Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728
- 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea
- NS3728 >=98% (HPLC)
- Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
- NS3728
- Endovion