H3B-120
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- CAS号:
- 2194903-42-7
- 英文名:
- H3B-120
- 英文别名:
- H3B-120;N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide;1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-;H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
- 中文名:
- H3B-120
- 中文别名:
- 化合物H3B-120;N1-苄基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺
- CBNumber:
- CB56193507
- 分子式:
- C19H24N4O2S
- 分子量:
- 372.48
- MOL File:
- 2194903-42-7.mol
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H3B-120化学性质
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密度:
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1.280±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 62.5 mg/mL (167.79 mM)
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酸度系数(pKa):
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8.28±0.70(Predicted)
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H3B-120性质、用途与生产工艺
H3B-120 是一种竞争性的、选择性的 carbamoyl phosphate synthetase 1 (CPS1) 变构抑制剂，其IC50值为1.5 μM，其Ki值为1.4 μM。H3B-120 表现出抗肿瘤活性。
| Target | Value |
CPS1
(Cell-free assay)
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1.4 μM(Ki)
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CPS1
(Cell-free assay)
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1.5 μM
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H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.
H3B-120
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136128 | H3B-120 | | 1 mg | 500元 |
| 2024/04/30 | HY-136128 | N1-苄基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺
H3B-120 | 2194903-42-7 | 10mM * 1mLin DMSO | 1078元 |
2194903-42-7, H3B-120 相关搜索:
- 药靶配体
- 化合物H3B-120
- N1-苄基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺
- 2194903-42-7
- 1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-
- H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
- N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide
- H3B-120