阿莫司汀
|
|
|
- CAS号:
- 75219-46-4
- 英文名:
- bestrabucil
- 英文别名:
- KM-2210;bestrabucil;Bestrabucil (KM2210);Estra-1,3,5(10)-triene-3,17β-diol 3-benzoate 17-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate;Estra-1,3,5(10)-triene-3,17-diol(17b)-, 3-benzoate17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate];Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
- 中文名:
- 阿莫司汀
- 中文别名:
- 化合物 T14344
- CBNumber:
- CB61306107
- 分子式:
- C41H47Cl2NO6
- 分子量:
- 720.729
- MOL File:
- 75219-46-4.mol
|
|
|
阿莫司汀化学性质
-
沸点:
-
804.3±65.0 °C(Predicted)
-
|
-
密度:
-
1.1424 (rough estimate)
-
|
-
折射率:
-
1.7350 (estimate)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
4.65±0.50(Predicted)
-
|
-
颜色:
-
Crystals
-
|
阿莫司汀性质、用途与生产工艺
Atrimustine 是苯丁酸氮芥与 β-雌二醇苯甲酸酯的结合物，具有抗肿瘤活性。
Atrimustine (Bestrabucil), a conjugate of chlorambucil and β-estradiol benzoate, has high affinity for tumor cells and enhances
the antitumor activity of chlorambucil.The effect of Atrimustine (Bestrabucil), a benzoate of an estradiol-chlorambucil conjugate, is examined on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line. At Atrimustine concentrations of 100 nM-10 μM, concentration-dependent inhibition of growth factor production by SC-115 cells can be demonstrated by
3
H-thymidine uptake assay.
类别
有毒物品
毒性分级
低毒
急性毒性
口服-大鼠 LD50: >6000 毫克/公斤; 口服-小鼠 LD50:>10000 毫克/公斤
储运特性
通风低温干燥
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
阿莫司汀
上下游产品信息
上游原料
下游产品
75219-46-4, 阿莫司汀 相关搜索:
- C41H47Cl2NO6
- 化合物 T14344
- 75219-46-4
- Estra-1,3,5(10)-triene-3,17-diol(17b)-, 3-benzoate17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
- Bestrabucil (KM2210)
- Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
- KM-2210
- Estra-1,3,5(10)-triene-3,17β-diol 3-benzoate 17-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate
- bestrabucil