阿比特龙代谢物
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- CAS号:
- 154229-21-7
- 英文名:
- 17-(3-pyridyl)androsta-5,16-dien-3-one
- 英文别名:
- CB-7627;D4-abiraterone;Δ4-Abiraterone;Δ4-Abiraterone;Abiraterone (D4A);3-Keto Abiraterone;Delta 4-Abiraterone;Abiraterone Impurity 59;Abiraterone Impurity 41;D4-abiraterone (CB-7627)
- 中文名:
- 阿比特龙代谢物
- 中文别名:
- 松香酮杂质41;阿比特龙代谢物;阿比特龙杂质41;阿比特龙杂质59;醋酸阿比特龙杂质19;2H4]-DELTA 4-阿比特龙;17-(3-吡啶基)-雄甾-4,16-二烯-3-酮;ABIRATERONE D4A METABOLITE|||CB-7627|||Δ4-ABIRATERONE
- CBNumber:
- CB61312708
- 分子式:
- C24H29NO
- 分子量:
- 347.49
- MOL File:
- 154229-21-7.mol
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阿比特龙代谢物化学性质
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沸点:
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504.6±50.0 °C(Predicted)
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密度:
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1.14±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 10 mg/ml
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形态:
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powder
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酸度系数(pKa):
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5.32±0.12(Predicted)
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颜色:
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white to beige
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阿比特龙代谢物性质、用途与生产工艺
D4-abiraterone 是阿比特龙的主要代谢产物。D4-abiraterone 是 CYP17A1, 3β-羟基类固醇脱氢酶 (3
βHSD) 和类固醇-5α-还原酶 ( SRD5A ) 的抑制剂，也是雄激素受体的拮抗剂。
CYP17A1, 3βHSD, SRD5A, androgen receptor
D4-abiraterone (D4A ) (10 mM) nearly completely blocks conversion from D4-androstenedione (AD) to 5α-androstanedione and other 5α-reduced androgens. The affinity of D4-abiraterone for mutant (expressed in LNCaP, half-maximum inhibitory concentration (IC
50
=5.3 nM)) and wild type (expressed in LAPC4, IC
50
=7.9 nM) androgen receptor (AR) is greater than that of abiraterone (Abi) (IC
50
=418 and >500 nM, respectively). Compare with Abi, D4-abiraterone clearly better suppresses PSA, TMPRSS2 and FKBP5 expression in LNCAP, LAPC4 and C4-2 cell lines. D4-abiraterone also inhibits AR target gene expression in a dose-dependent manner.
D4-abiraterone (D4A) is tenfold more potent than abiraterone (Abi) in blocking conversion from dehydroepiandrosterone (DHEA) by 3β-hydroxysteroid dehydrogenase (3βHSD) to D4-androstenedione (AD) in LNCaP and VCaP xenografts. 0.1 μM D4-abiraterone is equivalent to 1 μM Abi for blocking AD accumulation at 48 h in both LNCaP and VCaP xenografts. Progression is significantly delayed in the D4-abiraterone group compare with the Abi acetate group (P=0.011). D4-abiraterone treatment increases progression-free survival compare with Abi acetate.
阿比特龙代谢物
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-109619 | 阿比特龙代谢物
D4-abiraterone | 154229-21-7 | 5mg | 2800元 |
| 2024/04/30 | HY-109619 | 阿比特龙代谢物
D4-abiraterone | 154229-21-7 | 10mM * 1mLin DMSO | 3080元 |
154229-21-7, 阿比特龙代谢物 相关搜索:
- 142-醋酸阿比特龙
- ABIRATERONE D4A METABOLITE|||CB-7627|||Δ4-ABIRATERONE
- 阿比特龙杂质59
- 2H4]-DELTA 4-阿比特龙
- 阿比特龙杂质41
- 17-(3-吡啶基)-雄甾-4,16-二烯-3-酮
- 醋酸阿比特龙杂质19
- 松香酮杂质41
- 阿比特龙代谢物
- 154229-21-7
- Acetic acid abiolone impurity 19
- Δ4-Abiraterone
- 3-Keto Abiraterone
- Abiraterone Impurity 41
- Delta 4-Abiraterone
- Abiraterone Impurity 59
- Androsta-4,16-dien-3-one, 17-(3-pyridinyl)-
- (8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-1,7,8,9,10,11,12,13,14,15-decahydro-2H-cyclopenta[a]phenanthren-3(6H)-one
- (8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- CB-7627
- Abiraterone D4A metabolite
- (8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
- Δ4-Abiraterone
- Abiraterone (D4A)
- Abiraterone 3-Oxo 4,5-Dihydro Impurity/(8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-1,7,8,9,10,11,12,13,14,15-decahydro-2H-cyclopenta[a]phenanthren-3(6H)-one
- D4-abiraterone
- D4-abiraterone (CB-7627)
- 17-(3-pyridinyl)-androsta-4,16-diene-3-one
- 7-(3-pyridyl)androsta-5,16-dien-3-one
- 17-(3-pyridyl)androsta-5,16-dien-3-one