左旋多巴乙酯
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- CAS号:
- 37178-37-3
- 英文名:
- ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
- 英文别名:
- TV-1203;L-Dopa-Et;O-Ethyl-DOPA;L-DOPA Ethyl Ester;Levodopa ethyl ester;Levodopa Impurity 27;L-Dopa ethyl ester >=98% (HPLC);3-Hydroxy-L-tyrosine ethyl ester;L-Tyrosine, 3-hydroxy-, ethyl ester;3,4-Dihydroxy-L-phenylalanine ethyl ester
- 中文名:
- 左旋多巴乙酯
- 中文别名:
- 左旋多巴乙酯;左旋多巴杂质27;化合物 T15255;2(S)-氨基-3-(3,4-二羟基苯基)丙酸乙酯
- CBNumber:
- CB61568662
- 分子式:
- C11H15NO4
- 分子量:
- 225.24
- MOL File:
- 37178-37-3.mol
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左旋多巴乙酯化学性质
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沸点:
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394.2±37.0 °C(Predicted)
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密度:
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1.278±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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H2O: ≥12mg/mL at warmed to 60°C
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酸度系数(pKa):
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9.67±0.20(Predicted)
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形态:
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powder
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颜色:
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white to tan
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左旋多巴乙酯性质、用途与生产工艺
Etilevodopa (L-Dopa ethyl ester) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于研究帕金森病 (PD)。Levodopa 是多巴胺的直接前体，是一种合适的前体药物，有助于中枢神经系统的渗透和传递多巴胺。
Etilevodopa (L-Dopa ethyl ester) passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa.
Compared with standard Levodopa, Etilevodopa has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration.
左旋多巴乙酯
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37178-37-3, 左旋多巴乙酯 相关搜索:
- 抑制剂
- 左旋多巴杂质27
- 2(S)-氨基-3-(3,4-二羟基苯基)丙酸乙酯
- 化合物 T15255
- 左旋多巴乙酯
- 37178-37-3
- Levodopa Impurity 27
- L-Dopa ethyl ester >=98% (HPLC)
- L-Tyrosine, 3-hydroxy-, ethyl ester
- Levodopa ethyl ester
- L-Dopa-Et
- 3-Hydroxy-L-tyrosine ethyl ester
- 3,4-Dihydroxy-L-phenylalanine ethyl ester
- 2(S)-Amino-3-(3,4-dihydroxyphenyl)propionic acid ethyl ester
- L-DOPA Ethyl Ester
- ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
- TV-1203
- O-Ethyl-DOPA