化合物 T22992
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- CAS号:
- 186826-17-5
- 英文名:
- 2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE
- 英文别名:
- ML 10302;ML 10302 hydrochlorid;Monohydrochloride (9CI);2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE;2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate;2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
- 中文名:
- 化合物 T22992
- 中文别名:
- 化合物 T22992;ML 10302 盐酸盐;4-氨基-5-氯-2-甲氧基苯甲酸-2-(哌啶-1-基)乙基酯盐酸盐
- CBNumber:
- CB6207933
- 分子式:
- C15H22Cl2N2O3
- 分子量:
- 349.25
- MOL File:
- Mol file
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化合物 T22992化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: ~44 mg/mL
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形态:
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solid
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颜色:
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white
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化合物 T22992性质、用途与生产工艺
ML 10302 hydrochloride 是一种高效、选择性的 5-HT4 受体 (5-HT4 receptor) 激动剂,其 EC50 值为 4 nM。ML 10302 hydrochloride 对 5-HT4 的选择性结合作用比 5-HT3 至少高出 680 倍。
5-HT
4
Receptor
4 nM (EC
50
)
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5-HT
4
Receptor
1.07 nM (Ki)
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5-HT
3
Receptor
782 nM (Ki)
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ML 10302 hydrochloride shows
K
i
s of 1.07 nM and 782 nM for 5-HT
4
receptor and 5-HT
3
receptor, respectively, in binding assay.
ML 10302 hydrochloride (20 mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.
Animal Model:
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8-weeks old adult male C57BL/6j wild-type mice (23-27 g)
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Dosage:
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5 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:
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Subcutaneous injection
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Result:
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Significantly increased sAPPα level in the cortex.
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化合物 T22992
上下游产品信息
上游原料
下游产品
186826-17-5, 化合物 T22992 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- 药靶配体
- C15H21ClN2O3HCl
- C15H22Cl2N2O3
- C15H21ClN2O3
- ML 10302 盐酸盐
- 4-氨基-5-氯-2-甲氧基苯甲酸-2-(哌啶-1-基)乙基酯盐酸盐
- 化合物 T22992
- 186826-17-5
- 2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
- ML 10302 hydrochlorid
- 2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
- Monohydrochloride (9CI)
- 2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE
- ML 10302