网站主页 >> CAS数据库列表 >> 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
|
|
- CAS号:
- 1125593-20-5
- 英文名:
- 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
- 英文别名:
- Mps1-IN-1;Mps1 inhibitor;Mps1 inhibitor 1;Mps-1-IN-1,Mps1IN1,Mps1 IN 1;1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl;1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol;1MPS1-IN-1;1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL;4-Piperidinol, 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-
- 中文名:
- 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
- 中文别名:
- 化合物 T12102;MPS1抑制剂(MPS1-IN-1);1-[4-[[4-[[2-(异丙基磺酰基)苯基]氨基]-1H-吡咯并[2,3-B]吡啶-6-基]氨基]-3-甲氧基苯基]哌啶-4-醇
- CBNumber:
- CB62524940
- 分子式:
- C28H33N5O4S
- 分子量:
- 535.66
- MOL File:
- 1125593-20-5.mol
|
|
|
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol化学性质
-
密度:
-
1.354±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
insoluble in H2O; ≥16.05 mg/mL in DMSO; ≥9.26 mg/mL in EtOH
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
14.76±0.20(Predicted)
-
|
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol性质、用途与生产工艺
Mps1-IN-1 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50 和 Kd 值分别为 367 nM 和 27 nM。
Mps1
367 nM (IC
50
)
|
Mps1
27 nM (Kd)
|
ALK
21 nM (Kd)
|
LTK
29 nM (Kd)
|
PYK2
280 nM (Kd)
|
FAK
440 nM (Kd)
|
IGF1R
750 nM (Kd)
|
INSR
470 nM (Kd)
|
CLK1
1900 nM (Kd)
|
ERK2
2900 nM (Kd)
|
INSRR
1200 nM (Kd)
|
TNK1
2600 nM (Kd)
|
TNK2
3100 nM (Kd)
|
GAK
1100 nM (Kd)
|
Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC
50
and a K
d
of 367 nM and 27 nM. Mps1-IN-1 also has high affinity for ALK, and LTK, with K
d
s of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 (10 µM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 (5-10 µM) suppresses the proliferative capacity of HCT116.
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-13298 | Mps1-IN-1 | | 1 mg | 386元 |
2024/04/30 | HY-13298 | 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol Mps1-IN-1 | 1125593-20-5 | 5mg | 850元 |
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
生产厂家
1125593-20-5, 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol 相关搜索:
- 细胞生物学试剂
- 化合物 T12102
- MPS1抑制剂(MPS1-IN-1)
- 1-[4-[[4-[[2-(异丙基磺酰基)苯基]氨基]-1H-吡咯并[2,3-B]吡啶-6-基]氨基]-3-甲氧基苯基]哌啶-4-醇
- 1125593-20-5
- Mps-1-IN-1,Mps1IN1,Mps1 IN 1
- 4-Piperidinol, 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-
- Mps1 inhibitor 1
- Mps1 inhibitor
- 1MPS1-IN-1;1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
- Mps1-IN-1
- 1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl
- 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol