167626-17-7
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- CAS号:
- 167626-17-7
- 英文名:
- OPC-28326
- 英文别名:
- OPC-28326;OPC28326,OPC 28326;Propanamide, N-[2,6-dimethyl-4-[[4-[methyl(2-phenylethyl)amino]-1-piperidinyl]carbonyl]phenyl]-
- 中文名:
- 167626-17-7
- 中文别名:
- 化合物 T13804
- CBNumber:
- CB63175567
- 分子式:
- C26H35N3O2
- 分子量:
- 421.58
- MOL File:
- 167626-17-7.mol
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167626-17-7化学性质
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沸点:
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624.5±55.0 °C(Predicted)
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密度:
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1.13±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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14.79±0.70(Predicted)
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167626-17-7性质、用途与生产工艺
OPC-28326 是一种外周血管扩张药，同时为 α2-adrenergic receptor 的拮抗剂，对 α2A-，α2B- 和 α2C 肾上腺素受体的 Ki 值分别为 2040，285 和 55 nM。
Ki: 2040 nM (α2A adrenoceptor), 285 nM (α2B adrenoceptor), 55 nM (α2C adrenoceptor)
OPC-28326 enhances endothelial tube formation and promotes microvessel growth. OPC-28326 induces phosphorylation of eNOS and Akt in HAECs in a dose dependent-manner, while it does not affect total amounts of eNOS and Akt. OPC-28326 (1-100 μM) and yohimbine (10-1000 nM) causes a rightward shift in the concentration-response curve of clonidine.
OPC-28326 augments blood flow recovery in murine hindlimb ischemia. OPC-28326 significantly increases the number of histologically detectable capillaries in the ischemic leg. OPC-28326 has no beneficial effects on blood flow recovery in eNOS−/− mice. OPC-28326 (3-30 mg/kg, i.v.) and yohimbine causes dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. OPC-28326 does not affect on the mydriasis in rats.
167626-17-7
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下游产品
167626-17-7, 167626-17-7 相关搜索:
- 化合物 T13804
- 167626-17-7
- Propanamide, N-[2,6-dimethyl-4-[[4-[methyl(2-phenylethyl)amino]-1-piperidinyl]carbonyl]phenyl]-
- OPC28326,OPC 28326
- OPC-28326