RADIOPROTECTIN-1
|
|
|
- CAS号:
- 1622006-09-0
- 英文名:
- Radioprotectin-1
- 英文别名:
- Radioprotectin-1;Benzoic acid, 5-chloro-2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-
- 中文名:
- RADIOPROTECTIN-1
- 中文别名:
- 化合物 T12684;化合物RADIOPROTECTIN-1
- CBNumber:
- CB65419827
- 分子式:
- C23H19ClN2O6S
- 分子量:
- 486.92
- MOL File:
- 1622006-09-0.mol
|
|
|
RADIOPROTECTIN-1化学性质
-
沸点:
-
720.6±70.0 °C(Predicted)
-
|
-
密度:
-
1.490±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 125 mg/mL (256.72 mM);Water : < 0.1 mg/mL (insoluble)
-
|
-
酸度系数(pKa):
-
2.69±0.36(Predicted)
-
|
RADIOPROTECTIN-1性质、用途与生产工艺
Radioprotectin-1 是一种高效特异性的溶血磷脂酸受体 2 (LPA2) 激动剂，EC50 值为 25 nM (鼠源 LPA2 亚型) 。
EC50: 25 nM (murine LPA
2
subtype)
Radioprotectin-1 is a potent agonist of LPA
2
with an EC
50
of 5 pM and functions as a full agonist at the human ortholog of LPA
2
.
Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA
2
either endogenously or after transfection.
Cell Viability Assay
|
Cell Line:
|
MEF cells , IEC-6 cells
|
|
Concentration:
|
0 μM, 0.1 μM, 0.3 μM, 1.0 μM,3 μM
|
|
Incubation Time:
|
15 minutes
|
|
Result:
|
Protected cells from apoptosis by γ-irradiation- and the radiomimetic chemotherapeutic
Adiamycin.
|
Radioprotectin-1 is a high-potency specific agonist of the murine LPA
2
GPCR .
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA
2
GPCR in Lgr5
+
stem cells.
|
Animal Model:
|
8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI)
|
|
Dosage:
|
0.1 mg/kg, 0.3 mg/kg
|
|
Administration:
|
Subcutaneous injection; every 12 hours; for 3 days
|
|
Result:
|
Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
|
RADIOPROTECTIN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-114380 | Radioprotectin-1 | | 1 mg | 1480元 |
| 2024/04/30 | HY-114380 | RADIOPROTECTIN-1
Radioprotectin-1 | 1622006-09-0 | 5mg | 3700元 |
1622006-09-0, RADIOPROTECTIN-1 相关搜索:
- 化合物RADIOPROTECTIN-1
- 化合物 T12684
- 1622006-09-0
- Benzoic acid, 5-chloro-2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-
- Radioprotectin-1