KD-3010
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- CAS号:
- 934760-92-6
- 英文名:
- KD-3010
- 英文别名:
- KD-3010;KD 3010,KD3010
- 中文名:
- KD-3010
- 中文别名:
- 化合物KD-3010;化合物 T11747
- CBNumber:
- CB65821279
- 分子式:
- C30H33F3N2O8S2
- 分子量:
- 670.72
- MOL File:
- 934760-92-6.mol
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KD-3010化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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KD-3010性质、用途与生产工艺
KD-3010 是一种具有口服活性的有效的选择性 PPARδ 激动剂。
To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl
4
) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl
4
, and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl
4
on H&E-stained liver sections but is markedly reduced in the KD3010-treated group.
KD-3010
上下游产品信息
上游原料
下游产品
934760-92-6, KD-3010 相关搜索:
- 化合物KD-3010
- 化合物 T11747
- 934760-92-6
- KD 3010,KD3010
- KD-3010