Homocarbonyltopsentin
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- CAS号:
- 172286-77-0
- 英文名:
- Homocarbonyltopsentin
- 英文别名:
- PK4C9;Homocarbonyltopsentin;Methanone, [2-[(6-hydroxy-1H-indol-3-yl)carbonyl]-1H-imidazol-4-yl]-1H-indol-3-yl- (9CI)
- 中文名:
- Homocarbonyltopsentin
- 中文别名:
- 化合物 T13723
- CBNumber:
- CB65848744
- 分子式:
- C21H14N4O3
- 分子量:
- 370.36
- MOL File:
- 172286-77-0.mol
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Homocarbonyltopsentin化学性质
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熔点:
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>210 °C
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沸点:
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801.2±75.0 °C(Predicted)
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密度:
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1.539±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 125 mg/mL (337.51 mM)
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酸度系数(pKa):
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7.50±0.10(Predicted)
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Homocarbonyltopsentin性质、用途与生产工艺
Homocarbonyltopsentin (PK4C9) 是结合 TSL2 的小分子化合物,高羰基形成蛋白,
与 TSL2 的 pentaloop 构象结合并促进向三叶草构象的转变,增强 SMN2 外显子7 (E7) 剪接,EC50 值为 16 μM。
Homocarbonyltopsentin (PK4C9) (10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells.
Homocarbonyltopsentin (PK4C9) (40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO.
RT-PCR
Cell Line:
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GM03813C (SMA) cells; GM03814B fibroblasts cells
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Concentration:
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10-40 μM
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Incubation Time:
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24 hours
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Result:
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E7 inclusion reached a maximum of 91% (25% increase, DMSO-treated cells).
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Western Blot Analysis
Cell Line:
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GM03813C (SMA) cells; GM03814B fibroblasts cells
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Concentration:
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40 μM
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Incubation Time:
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24 hours
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Result:
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Increased SMN protein in SMA cells.
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Homocarbonyltopsentin
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-117389 | Homocarbonyltopsentin Homocarbonyltopsentin | 172286-77-0 | 5mg | 2200元 |
2024/04/30 | HY-117389 | Homocarbonyltopsentin | | 10 mg | 3500元 |
Homocarbonyltopsentin
生产厂家
172286-77-0, Homocarbonyltopsentin 相关搜索:
- 化合物 T13723
- 172286-77-0
- Methanone, [2-[(6-hydroxy-1H-indol-3-yl)carbonyl]-1H-imidazol-4-yl]-1H-indol-3-yl- (9CI)
- PK4C9
- Homocarbonyltopsentin