136941-85-0
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- CAS号:
- 136941-85-0
- 英文名:
- PCA 50941
- 英文别名:
- PCA 50941;PCA-50941,PCA50941;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-[(tetrahydro-2H-pyran-2-yl)methyl] ester
- 中文名:
- 136941-85-0
- 中文别名:
- 化合物 T13812
- CBNumber:
- CB71336572
- 分子式:
- C30H31N3O10S
- 分子量:
- 625.64624
- MOL File:
- 136941-85-0.mol
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136941-85-0化学性质
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沸点:
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816.6±75.0 °C(Predicted)
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密度:
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1.387±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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2.60±0.70(Predicted)
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136941-85-0性质、用途与生产工艺
PCA50941 是 1，4-二氢吡啶衍生物，可用于心血管疾病的研究。
PCA50941 (1 μM) shifts the I-V relationship of whole-cell Ca
2+
currents by about 5-10 mV towards more hyperpolarizing potentials. PCA50941 increases further the K(+)-evoked peak to 655 nM. In the presence of 5 mM Ca
2+
, PCA50941 increases the [Ca
2+
] peaks to 427 nM. PCA50941 potentiates the release of catecholamines from perfused bovine adrenal glands evoked by 30 s pulses of 17.7 mM K
+
in a manner dependent on the [Ca
2+
]o.
PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals.
136941-85-0
上下游产品信息
上游原料
下游产品
136941-85-0, 136941-85-0 相关搜索:
- C30H31N3O10S
- 化合物 T13812
- 136941-85-0
- PCA-50941,PCA50941
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-[(tetrahydro-2H-pyran-2-yl)methyl] ester
- PCA 50941