化合物 T11797
|
|
|
- CAS号:
- 142523-14-6
- 英文名:
- 1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE
- 英文别名:
- L-690,488;L 690488,L690488;1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE;Propanoic acid, 2,2-dimethyl-, [1-(4-hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)] ester (9CI)
- 中文名:
- 化合物 T11797
- 中文别名:
- 化合物 T11797
- CBNumber:
- CB7169913
- 分子式:
- C32H52O16P2
- 分子量:
- 754.69
- MOL File:
- 142523-14-6.mol
|
|
|
化合物 T11797化学性质
-
沸点:
-
754.8±60.0 °C(Predicted)
-
|
-
密度:
-
1.232±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -80°C
-
|
-
酸度系数(pKa):
-
9.55±0.15(Predicted)
-
|
化合物 T11797性质、用途与生产工艺
L-690488 是一种 L-690330 的前药，也是一种选择性的肌醇单磷酸酶 (IMPase) 抑制剂。L-690488 比 L-690330 具有更有效的细胞穿透能力。
Inositol monophosphatase (IMPase)
The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC
50
values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [
3
H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC
50
values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively).
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion.
化合物 T11797
上下游产品信息
上游原料
下游产品
142523-14-6, 化合物 T11797 相关搜索:
- C32H52O16P2
- 化合物 T11797
- 142523-14-6
- L 690488,L690488
- Propanoic acid, 2,2-dimethyl-, [1-(4-hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)] ester (9CI)
- L-690,488
- 1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE