网站主页 >> CAS数据库列表 >> ((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物
((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物
|
|
|
- CAS号:
- 107220-28-0
- 英文名:
- Cevimeline Hydrochloride Salt
- 英文别名:
- SNK 508;Fks 508;Snd 5008;Saligren;CeviMelin;rac-Cevimeline HCl;AF-102B hydrochloride;SNI-2011 hydrochloride;Cevimelin Hydrochloride;CEVIMELINE, HYDROCHLORIDE SALT
- 中文名:
- ((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物
- 中文别名:
- 西维美林-D4盐酸盐盐
- CBNumber:
- CB72130375
- 分子式:
- C10H18ClNOS
- 分子量:
- 235.77402
- MOL File:
- 107220-28-0.mol
|
|
|
((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物化学性质
-
熔点:
-
195-197?C
-
|
-
储存条件:
-
Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM)
-
|
-
形态:
-
A crystalline solid
-
|
-
稳定性:
-
Hygroscopic
-
|
((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物性质、用途与生产工艺
Cevimeline hydrochloride (AF102B hydrochloride) 是一种乙酰胆碱的奎尼丁衍生物，也是一种选择性的和口服活性的毒蕈碱型 M1 和 M3 受体激动剂。Cevimeline hydrochloride 可刺激唾液腺分泌，并可用作口干症的一种催涎剂。Cevimeline hydrochloride 可穿过血脑屏障。
Muscarinic M1 and M3 receptor
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca
2+
concentration.
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.
|
Animal Model:
|
Male Wistar rats (8-week-old) injected with angiotensin-II
|
|
Dosage:
|
0.008 mg/kg, 0.016 mg/kg
|
|
Administration:
|
Intraperitoneal injection
|
|
Result:
|
Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
|
((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物
上下游产品信息
上游原料
下游产品
((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物
生产厂家
107220-28-0, ((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物 相关搜索:
- API
- Pharmaceuticals
- Neurochemicals
- Intermediates & Fine Chemicals
- Heterocycles
- 西维美林-D4盐酸盐盐
- 107220-28-0
- rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride
- rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride
- Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane],2'-methyl-, hydrochloride (1:1), (2'R,3R)-rel-
- rac-Cevimeline HCl
- 2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane],hydrochloride
- Cevimelin Hydrochloride
- AF-102B HYDROCHLORIDE;SNI-2011 HYDROCHLORIDE
- SNI-2011 hydrochloride
- AF-102B hydrochloride
- rac,cis-Cevimeline Hydrochloride Salt
- Cevimeline D4 hydrochlorideQ: What is
Cevimeline D4 hydrochloride Q: What is the CAS Number of
Cevimeline D4 hydrochloride Q: What is the storage condition of
Cevimeline D4 hydrochloride Q: What are the applications of
Cevimeline D4 hydrochloride
- CeviMeline hydrochloride Saligren
- CeviMelin
- SNK 508
- (2'R,3R)-rel-2'-Methyl- spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] hydrochloride
- cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]hydrochloride
- Snd 5008
- Saligren
- Fks 508
- CEVIMELINE, HYDROCHLORIDE SALT