Resolvin D2
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- CAS号:
- 810668-37-2
- 英文名:
- Resolvin D2
- 英文别名:
- RvD2;IKFAUGXNBOBQDM-XFMPMKITSA-N;4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-
- 中文名:
- Resolvin D2
- 中文别名:
- CBNumber:
- CB72592373
- 分子式:
- C22H32O5
- 分子量:
- 376.49
- MOL File:
- 810668-37-2.mol
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Resolvin D2化学性质
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沸点:
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609.2±55.0 °C(Predicted)
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密度:
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1.101±0.06 g/cm3(Predicted)
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储存条件:
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Store at -80°C,protect from light
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溶解度:
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DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .05 mg/ml
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酸度系数(pKa):
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4.58±0.10(Predicted)
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Resolvin D2性质、用途与生产工艺
Resolvin D2 是 DHA 的代谢物，具有抗炎和抗感染活性。Resolvin D2 是一种高效的白细胞调节器，能控制微生物败血症。在原代感觉神经元中，Resolvin D2 是 TRPV1 (IC50 = 0.1 nM) 和 TRPA1 (IC50 = 2 nM) 的有效抑制剂。
Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions.
Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression.
Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain.
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Animal Model:
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Adult CD1 mice (male, 8–10 weeks)
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Dosage:
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10 ng
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Administration:
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Intraplantar administration
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Result:
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Inhibited inflammatory pain.
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Resolvin D2
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810668-37-2, Resolvin D2 相关搜索:
- 810668-37-2
- 4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-
- RvD2
- IKFAUGXNBOBQDM-XFMPMKITSA-N