1621884-22-7
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- CAS号:
- 1621884-22-7
- 英文名:
- AODDRWVLAXJCBA-UHFFFAOYSA-N
- 英文别名:
- PSI-7409 tetrasodium;AODDRWVLAXJCBA-UHFFFAOYSA-N;PSI 7409 tetrasodium,PSI7409 tetrasodium;2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt
- 中文名:
- 1621884-22-7
- 中文别名:
- 化合物 T13852
- CBNumber:
- CB73595995
- 分子式:
- C10H17FN2NaO14P3
- 分子量:
- 524.16
- MOL File:
- 1621884-22-7.mol
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1621884-22-7化学性质
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储存条件:
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Store at -20°C
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水溶解性:
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Water : ≥ 125 mg/mL (211.11 mM)
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1621884-22-7性质、用途与生产工艺
PSI-7409 tetrasodium 是一种 sofosbuvir (PSI-7977) 的 5'-三磷酸活性代谢物，能够抑制 HCV NS5B polymerases，对 GT 1b_Con1，GT 2a_JFH1，GT 3a 和 GT 4a NS5B 聚合酶的 IC50 值分别为 1.6，2.8，0.7 和 2.6 μM。
IC50: 1.6 μM (GT 1b_Con1), 2.8 μM (GT 2a_JFH1), 0.7 μM (GT 3a), 2.6 μM (GT 4a)
PSI-7409 tetrasodium is an active 5'-triphosphate metabolite, inhibiting HCV NS5B polymerases, with IC
50
s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. PSI-7409 also weakly inhibits human DNA polymerase α, with an IC
50
of 550 μM, but shows no inhibition on DNA Pol β and γ. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μM over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ∼100 μM at 4 h and remains at that concentration for 48 h.
1621884-22-7
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15745A | 1621884-22-7
PSI-7409 tetrasodium | 1621884-22-7 | 1mg | 2600元 |
| 2024/04/30 | HY-15745A | 1621884-22-7
PSI-7409 tetrasodium | 1621884-22-7 | 5mg | 7800元 |
1621884-22-7, 1621884-22-7 相关搜索:
- 化合物 T13852
- 1621884-22-7
- PSI 7409 tetrasodium,PSI7409 tetrasodium
- 2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt
- PSI-7409 tetrasodium
- AODDRWVLAXJCBA-UHFFFAOYSA-N