Lin28-IN-1
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- CAS号:
- 2024548-03-4
- 英文名:
- Lin28-IN-1
- 英文别名:
- Lin28-IN-1;Lin28-let-7a antagonist 1;Inhibitor,inhibit,MicroRNA,Lin-28-let-7a antagonist 1,Lin28 let 7a antagonist 1,miRNA,Lin28let7a antagonist 1;4-(7-(4-((Benzyloxy)carbonyl)piperazin-1-yl)-4,4-dimethyl-8-nitrochromeno[4,3-c]pyrazol-1(4H)-yl)benzoic acid;1-Piperazinecarboxylic acid, 4-[1-(4-carboxyphenyl)-1,4-dihydro-4,4-dimethyl-8-nitro[1]benzopyrano[4,3-c]pyrazol-7-yl]-, 1-(phenylmethyl) ester
- 中文名:
- Lin28-IN-1
- 中文别名:
- 化合物LIN28-LET-7A ANTAGONIST 1;4-(7-(4-((苯甲氧基)羰基)哌嗪-1-基)-4,4-二甲基-8-硝基苯并吡喃并[4,3-C]吡唑-1(4H)-基)苯甲酸
- CBNumber:
- CB74668133
- 分子式:
- C31H29N5O7
- 分子量:
- 583.59
- MOL File:
- 2024548-03-4.mol
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Lin28-IN-1化学性质
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沸点:
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813.8±65.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.72±0.10(Predicted)
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Lin28-IN-1性质、用途与生产工艺
Lin28-let-7a antagonist 1 对 Lin28-let-7a 的结合有明显的拮抗作用，其对 Lin28A-let-7a-1 结合的 IC50 值为 4.03 μM。
IC50：4.03 μM (Lin28A-let-7a-1).
Lin28-let-7a antagonist 1 (compound 1) shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC
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of 4.03 μM. Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency. Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA. When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.
Lin28-IN-1
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100692 | 4-(7-(4-((苯甲氧基)羰基)哌嗪-1-基)-4,4-二甲基-8-硝基苯并吡喃并[4,3-C]吡唑-1(4H)-基)苯甲酸
Lin28-let-7a antagonist 1 | 2024548-03-4 | 5mg | 3700元 |
| 2024/04/30 | HY-100692 | 4-(7-(4-((苯甲氧基)羰基)哌嗪-1-基)-4,4-二甲基-8-硝基苯并吡喃并[4,3-C]吡唑-1(4H)-基)苯甲酸
Lin28-let-7a antagonist 1 | 2024548-03-4 | 10mM * 1mLin DMSO | 4750元 |
2024548-03-4, Lin28-IN-1 相关搜索:
- C31H29N5O7
- 化合物LIN28-LET-7A ANTAGONIST 1
- 4-(7-(4-((苯甲氧基)羰基)哌嗪-1-基)-4,4-二甲基-8-硝基苯并吡喃并[4,3-C]吡唑-1(4H)-基)苯甲酸
- 2024548-03-4
- Inhibitor,inhibit,MicroRNA,Lin-28-let-7a antagonist 1,Lin28 let 7a antagonist 1,miRNA,Lin28let7a antagonist 1
- 4-(7-(4-((Benzyloxy)carbonyl)piperazin-1-yl)-4,4-dimethyl-8-nitrochromeno[4,3-c]pyrazol-1(4H)-yl)benzoic acid
- 1-Piperazinecarboxylic acid, 4-[1-(4-carboxyphenyl)-1,4-dihydro-4,4-dimethyl-8-nitro[1]benzopyrano[4,3-c]pyrazol-7-yl]-, 1-(phenylmethyl) ester
- Lin28-let-7a antagonist 1
- Lin28-IN-1