SS28
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- CAS号:
- 141172-08-9
- 英文名:
- SS28
- 英文别名:
- SS28;SS28,SS-28;Benzene, 1,2,3-trimethoxy-5-[(1Z)-2-(4-methylphenyl)ethenyl]-
- 中文名:
- SS28
- 中文别名:
- 化合物 T13901
- CBNumber:
- CB75821201
- 分子式:
- C18H20O3
- 分子量:
- 284.35
- MOL File:
- 141172-08-9.mol
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SS28化学性质
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沸点:
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414.3±40.0 °C(Predicted)
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密度:
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1.089±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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SS28性质、用途与生产工艺
SS28是具有口服生物利用度的SRT501 类似物，可抑制微管蛋白聚合，在G2/M引起细胞周期阻滞。SS28会引起细胞凋亡而不是坏死。
SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines.
SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation.
Cell Proliferation Assay
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Cell Line:
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CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.
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Concentration:
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1, 5, 10 and 20 μM.
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Incubation Time:
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48 and 72 h.
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Result:
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CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48 h of the treatment. IC
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values of SS28 in CEM and A549 cell line were 2.6 and 5.2 μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21 μ M, respectively after 48 h of treatment.
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Cell Cycle Analysis
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Cell Line:
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CEM and A549 cells.
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Concentration:
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2 μM (CEM) and 5 μM (A549).
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Incubation Time:
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6, 12, 18, 24 and 30 h.
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Result:
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Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24 h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30 h in case of A549. Similarly, studies in CEM also showed a distinct G2/M arrest after 12 h of treatment, as compared to vehicle control.
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SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation.
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Animal Model:
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BALB/c mice using EAC cells.
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Dosage:
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15 mg/kg.
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Administration:
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Orally on every alternate day for 9 doses.
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Result:
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There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.
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SS28
上下游产品信息
上游原料
下游产品
141172-08-9, SS28 相关搜索:
- 化合物 T13901
- 141172-08-9
- SS28,SS-28
- Benzene, 1,2,3-trimethoxy-5-[(1Z)-2-(4-methylphenyl)ethenyl]-
- SS28