6-methyl-1,3,8-trichlorodibenzofuran
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- CAS号:
- 115039-00-4
- 英文名:
- 6-methyl-1,3,8-trichlorodibenzofuran
- 英文别名:
- 6-MCDF;AhR modulator-1;AhR modulator 1,AhR modulator1;6-methyl-1,3,8-trichlorodibenzofuran
- 中文名:
- 6-methyl-1,3,8-trichlorodibenzofuran
- 中文别名:
- 化合物 T10273
- CBNumber:
- CB81333417
- 分子式:
- 分子量:
- 0
- MOL File:
- 115039-00-4.mol
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6-methyl-1,3,8-trichlorodibenzofuran化学性质
6-methyl-1,3,8-trichlorodibenzofuran性质、用途与生产工艺
AhR modulator-1 (compound 6-MCDF) 是一种选择性的口服活性芳烃受体 (AhR) 调节剂。AhR modulator-1 部分地通过在肿瘤形成之前抑制前列腺 VEGF 的产生而抑制肿瘤转移。AhR modulator-1 在大鼠子宫中也具有抗雌激素特性。
Aryl hydrocarbon receptor (AhR)
Prostatic VEGF
Estrogenic
AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively.
Cell Proliferation Assay
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Cell Line:
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ASPC-1 cells
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Concentration:
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0.1 μM, 1 μM and 10 μM
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Incubation Time:
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48 hours, 72 hours, 96 hours
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Result:
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Exhibited dose-dependent growth inhibitory effects.
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AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced.
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Animal Model:
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C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old)
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Dosage:
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0 mg/kg, 10 mg/kg, 40 mg/kg
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Administration:
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Oral administration; daily; for 12 weeks
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Result:
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The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced.
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6-methyl-1,3,8-trichlorodibenzofuran
上下游产品信息
上游原料
下游产品
6-methyl-1,3,8-trichlorodibenzofuran
生产厂家
115039-00-4, 6-methyl-1,3,8-trichlorodibenzofuran 相关搜索:
- 化合物 T10273
- 115039-00-4
- AhR modulator 1,AhR modulator1
- AhR modulator-1
- 6-MCDF
- 6-methyl-1,3,8-trichlorodibenzofuran