Unii-T4np8G3K6q

生物活性靶点体外研究体内研究 Unii-T4np8G3K6q 试剂级价格

Unii-T4np8G3K6q

CAS号:: 195533-53-0

英文名:: Unii-T4np8G3K6q

英文别名:: Tl 057;T 138067;Batabulin;Batabulin [inn];Unii-T4np8G3K6q;2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide;N-(3-Fluoro-4-methoxyphenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide;Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-;multidrug-resistant,Batabulin,T-138067,polymerization,cytoskeleton,covalent,Apoptosis,Cys-239,β-tubulin,arrest,Inhibitor,Microtubule/Tubulin,T 138067,Antimitotic,inhibit,cell-cycle,antitumor

中文名:: Unii-T4np8G3K6q

中文别名:: 巴他布林;化合物BATABULIN

CBNumber:: CB82494683

分子式:: C13H7F6NO3S

分子量:: 371.26

MOL File:: 195533-53-0.mol

化学性质安全信息用途价格供应商 13

Unii-T4np8G3K6q化学性质

沸点:: 403.3±55.0 °C(Predicted)

密度:: 1.629±0.06 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO: 100 mg/mL (269.35 mM)

酸度系数(pKa):: 5.74±0.10(Predicted)

安全信息

Unii-T4np8G3K6q性质、用途与生产工艺

生物活性

Batabulin (T138067) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管 (microtubule) 聚合。Batabulin 影响细胞形态并导致细胞周期停滞，最终诱导凋亡性细胞死亡。

Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary.
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis.
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy.

Cell Cycle Analysis

Cell Line:	MCF7 cells
Concentration:	30 nM, 100 nM and 300 nM
Incubation Time:	24 hours
Result:	Showed an arrest at the G2/M cell-cycle boundary.

Apoptosis Analysis

Cell Line:	MCF7 cells
Concentration:	30 nM, 100 nM and 300 nM
Incubation Time:	24 hours or 48 hours
Result:	25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.

体内研究

Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors.

Animal Model:	Male athymic nude mice ( nu/nu ) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells
Dosage:	40 mg/kg
Administration:	Intraperitoneal injection; once per week; on days 5, 12, and 19
Result:	Impaired the growth of the drug-sensitive CCRF-CEM tumors.

Unii-T4np8G3K6q 上下游产品信息

上游原料

下游产品

Unii-T4np8G3K6q 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-13563	Batabulin		1 mg	550元
2024/04/30	HY-13563	Unii-T4np8G3K6q Batabulin	195533-53-0	5mg	1500元

Unii-T4np8G3K6q 生产厂家

全球有 13家供应商 Unii-T4np8G3K6q国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
北京普西唐生物科技有限公司	010-60605840 18892239720	psaitong@jm-bio.com	中国	12308	58
上海林栎医药科技有限公司	13761635123	1014988033@qq.com	中国	4986	55
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	美国	19553	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
上海一研生物科技有限公司	021-69985186 13611928337	3427709316@qq.com	中国	7984	58
上海陌孚医药科技有限公司	021-59167510 18117107507	vip@med-life.cn	中国	5019	58
南京世洲生物科技有限公司	025-85560043 15850508050	cindy.huang@synzest.com	中国	12007	58
銳迪國際科技有限公司	18024082417	market@ubiochem.com	中国	9180	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	52927	58

195533-53-0, Unii-T4np8G3K6q 相关搜索:

抑制剂
C13H7F6NO3S
化合物BATABULIN
巴他布林
195533-53-0
multidrug-resistant,Batabulin,T-138067,polymerization,cytoskeleton,covalent,Apoptosis,Cys-239,β-tubulin,arrest,Inhibitor,Microtubule/Tubulin,T 138067,Antimitotic,inhibit,cell-cycle,antitumor
2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide
Unii-T4np8G3K6q
Tl 057
T 138067
N-(3-Fluoro-4-methoxyphenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide
Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-
Batabulin [inn]
Batabulin