7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇
|
|
|
- CAS号:
- 6964-62-1
- 英文名:
- Nsc66811
- 英文别名:
- Nsc66811;NSC 66811; NSC66811; NSC-66811;7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol;7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol;2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol;2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol;8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-;8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
- 中文名:
- 7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇
- 中文别名:
- NSC 66811游离态;2-甲基-7-[苯基(苯氨基)甲基]-8-喹啉醇;2-甲基-7-(苯基(苯氨基)甲基)喹啉-8-醇;7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇
- CBNumber:
- CB82498106
- 分子式:
- C23H20N2O
- 分子量:
- 340.42
- MOL File:
- 6964-62-1.mol
|
|
|
7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇化学性质
-
熔点:
-
143.0 to 147.0 °C
-
|
-
沸点:
-
529.5±45.0 °C(Predicted)
-
|
-
密度:
-
1.235±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Keep in dark place,Inert atmosphere,2-8°C
-
|
-
溶解度:
-
Soluble in DMSO (up to 25 mg/ml).
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
4.42±0.50(Predicted)
-
|
-
颜色:
-
White
-
|
-
最大波长(λmax):
-
250nm(EtOH)(lit.)
-
|
-
稳定性:
-
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
-
|
7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇性质、用途与生产工艺
NSC 66811 是一个MDM2-p53 抑制剂，其结合到MDM2 的 Ki 值为 120 nM。
NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21
cip1/waf
due to the functional activation of p53.
Western Blot Analysis
|
Cell Line:
|
HCT-116 (p53
+/+
and p53
-/-
) cells
[1]
.
|
|
Concentration:
|
0, 5, 10, 20 μM.
|
|
Incubation Time:
|
48 h.
|
|
Result:
|
Dose-dependently induced the accumulation of p53, MDM2, and p21
cip1/waf
proteins in the HCT-116 human colon cancer cell line with wild-type p53.
Had no effect on the levels for p53, MDM2, and p21
cip1/waf
protein in the isogenic HCT-116 p53
-/-
cell line.
|
7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | M2390 | 2-甲基-7-[苯基(苯氨基)甲基]-8-喹啉醇
2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol | 6964-62-1 | 25mg | 165元 |
| 2024/04/30 | HY-14967 | NSC 66811 | | 1 mg | 304元 |
7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇
生产厂家
6964-62-1, 7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇 相关搜索:
- 2-甲基-7-[苯基(苯氨基)甲基]-8-喹啉醇
- NSC 66811游离态
- 2-甲基-7-(苯基(苯氨基)甲基)喹啉-8-醇
- 7-(ALPHA-苯胺基苄基)-2-甲基-8-喹啉醇
- 6964-62-1
- 2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol
- 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol
- 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
- NSC 66811; NSC66811; NSC-66811
- 8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-
- 7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol
- 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
- Nsc66811