864668-87-1
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- CAS号:
- 864668-87-1
- 英文名:
- ENMD-119
- 英文别名:
- ENMD-119;ENMD 1198;IRC 110160;ENMD-119 (ENMD 1198);Estra-1,3,5(10),16-tetraene-3-carboxamide, 2-methoxy-
- 中文名:
- 864668-87-1
- 中文别名:
- 化合物 T15234
- CBNumber:
- CB82627803
- 分子式:
- C20H25NO2
- 分子量:
- 311.42
- MOL File:
- 864668-87-1.mol
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864668-87-1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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864668-87-1性质、用途与生产工艺
ENMD-1198 (IRC-110160)，具有口服活性的微管 (microtubule) 靶向剂，是 2-methoxyestradiol 的类似物，具有抗肿瘤、抗血管生成功效，在人体 HCC 细胞中，ENMD-1198 抑制人肝癌细胞中的 HIF-1α 和 STAT3，并导致肿瘤生长和血管生成减少。
ENMD-1198 (0-5 μM; 24 hours) leads to a significant dose-dependent inhibition of HCC cell growth with IC
50
s of 2.5 μM for HUH-7 and HepG2 cells, respectively.
ENMD-1198 (2.5 μM; 16 hours) abrogates EGF-induced phosphorylation of Akt (HUH-7), FAK (HUH-7), p44/42 MAPK (HepG2), and STAT3 (HUH-7, HepG2).
Cell Viability Assay
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Cell Line:
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HUH-7 and HepG2 cells
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Concentration:
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0-5 μM
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Incubation Time:
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24 hours
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Result:
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Led to a significant dose-dependent inhibition of HCC cell growth.
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Western Blot Analysis
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Cell Line:
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HUH-7 and HepG2 cells
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Concentration:
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2.5 μM
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Incubation Time:
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16 hours
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Result:
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Abrogated EGF-induced phosphorylation of Akt (HUH-7), FAK (HUH-7), p44/42 MAPK (HepG2), and STAT3 (HUH-7, HepG2).
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ENMD-1198 (200 mg/kg; p.o.; daily from day 7 to day 19) effectively inhibits growth of hepatocellular carcinoma through direct effects on the tumor cells, and also through inhibition of angiogenesis.
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Animal Model:
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Eight-week-old male athymic nude mice (BALB/c nu/nu) (xenografted hepatocellular tumors)
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Dosage:
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200 mg/kg
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Administration:
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P.o.; daily from day 7 to day 19
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Result:
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Led to a significant growth inhibition of xenografted hepatocellular tumors.
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864668-87-1
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16196 | 864668-87-1
ENMD-1198 | 864668-87-1 | 1mg | 5000元 |
| 2024/01/25 | HY-16196 | ENMD-1198 | | 10 mM * 1 mLin DMSO | 17128元 |
864668-87-1, 864668-87-1 相关搜索:
- 化合物 T15234
- 864668-87-1
- Estra-1,3,5(10),16-tetraene-3-carboxamide, 2-methoxy-
- ENMD-119 (ENMD 1198)
- IRC 110160
- ENMD 1198
- ENMD-119