Ro-15-2041
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- CAS号:
- 77448-87-4
- 英文名:
- Ro-15-2041
- 英文别名:
- Ro152041,Ro 15 2041;Imidazo[2,1-b]quinazolin-2(3H)-one, 7-bromo-1,5-dihydro-3,6-dimethyl-
- 中文名:
- Ro-15-2041
- 中文别名:
- 化合物 T12741
- CBNumber:
- CB83175576
- 分子式:
- C12H12BrN3O
- 分子量:
- 294.15
- MOL File:
- 77448-87-4.mol
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Ro-15-2041化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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Ro-15-2041性质、用途与生产工艺
Ro 15-2041是选择性血小板磷酸二酯酶抑制剂,具有抗血栓性质。
Ro 15-2041 inhibits platelet aggregation induced by all common platelet agonists in platelet-rich plasma obtained from various species including man (IC
50
=1-3 μM). Ro 15-2041 potentiates platelet inhibition by prostacyclin, the prostacyclin-induced increase of intraplatelet cyclic (c) AMP levels and inhibits the collagen-induced release of serotonin and beta-thromboglobulin. Ro 15-2041 reduces the increase and accelerated the normalization of cytosolic free Ca
2+
in thrombin-stimulated human platelets. Ro 15-2041 is a potent (IC
50
=70 nM) and selective inhibitor of platelet cAMP-phosphodiesterase activity. Whereas Ro 15-2041 causes complete inhibition of cAMP-phosphodiesterase activity in human platelet supernatants, breakdown of cAMP in cardiac homogenates is depressed to maximally 50%. In human brain and rabbit uterus Ro 15-2041 is at least 1000 times less potent. By comparison, papaverine fully inhibits phosphodiesterase activity in all four tissues with similar IC
50
values of about 5 μM. Furthermore, Ro 15-2041 selectively inhibits cAMP-phosphodiesterase activity of a bovine calmodulin-independent but not of a calmodulin-dependent enzyme preparation.
Ro-15-2041
上下游产品信息
上游原料
下游产品
77448-87-4, Ro-15-2041 相关搜索:
- 化合物 T12741
- 77448-87-4
- Ro152041,Ro 15 2041
- Imidazo[2,1-b]quinazolin-2(3H)-one, 7-bromo-1,5-dihydro-3,6-dimethyl-