FCE 28654
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- CAS号:
- 169474-77-5
- 英文名:
- Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
- 英文别名:
- FCE 28654;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
- 中文名:
- FCE 28654
- 中文别名:
- 化合物 T13262
- CBNumber:
- CB83339727
- 分子式:
- C25H35N2O7P
- 分子量:
- 506.53
- MOL File:
- 169474-77-5.mol
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FCE 28654化学性质
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密度:
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1.242±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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1.22±0.30(Predicted)
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FCE 28654性质、用途与生产工艺
FCE 28654 是一种水溶的酰基 COA: 胆固醇酰基转移酶 (ACAT) 抑制剂，在兔主动脉、肠和猴肝脏的微粒体中，抑制 ACAT 的活性，IC50 值分别为 2.55，1.08 和 5.69 μM。
IC50: 2.55 μM (ACAT, Rabbit aorta), 1.08 μM (ACAT, Rabbit intestine), 5.69 μM (ACAT, Monkey liver)
FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC
50
s of 2.55, 1.08 and 5.69 μM, respcetively.
FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma.
FCE 28654
上下游产品信息
上游原料
下游产品
169474-77-5, FCE 28654 相关搜索:
- 抑制剂
- 化合物 T13262
- 169474-77-5
- FCE 28654
- Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-