4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

生物活性靶点体外研究体内研究 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide 试剂级价格

CAS号:: 94345-47-8

英文名:: 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

英文别名:: SBi4211;Heptamidine;Benzenecarboximidamide, 4,4'-[1,7-heptanediylbis(oxy)]bis-;4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

中文名:: 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

中文别名:: 化合物 T11553L;4,4'-(庚烷-1,7-二基双(氧基))二苯甲脒

CBNumber:: CB83672565

分子式:: C21H28N4O2

分子量:: 368.47

MOL File:: 94345-47-8.mol

化学性质安全信息用途价格供应商 7

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide化学性质

熔点:: 175-177 °C (decomp)

沸点:: 558.0±60.0 °C(Predicted)

密度:: 1.17±0.1 g/cm3(Predicted)

酸度系数(pKa):: 12.81±0.50(Predicted)

安全信息

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide性质、用途与生产工艺

生物活性

Heptamidine (SBi4211) 是一种强效的 Pentamidine-related 钙结合蛋白 S100B 的抑制剂 (Kd=6.9 μM)，选择性地杀死表达 S100B 的黑素瘤细胞。Heptamidine 是研究强直性肌营养不良 (DM) 的有效工具。

靶点

Kd: 6.9 μM (calcium-binding protein S100B)

Heptamidine is a Pentamidine-S100B complex, two molecules of pentamidine bind per monomer of S100B, which performs to be an inhibitor for S100B.Heptamidine (20 μM) does not decrease CUG levels significantly when compares to Propamidine and Pentamidine, and exhibits cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats.Heptamidine rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC ₅₀ value of 15 μM.

体内研究

Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in HSA LR mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg.

Animal Model:	Homozygous HSALR transgenic mice in line 20b (FVB inbred background) with a Myotonic dystrophy (DM) mouse model
Dosage:	20 or 30 mg/kg
Administration:	Intraperitoneal injection; 7 days; once daily
Result:	Reversed splicing defects and rescues myotonia in a DM mouse model.

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide 上下游产品信息

上游原料

下游产品

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2023/03/20	HY-16918	4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Heptamidine	94345-47-8	5mg	2100元
2023/03/20	HY-16918	4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide Heptamidine	94345-47-8	10mg	3360元

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide 生产厂家

全球有 7家供应商 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
天津凯利奇生物科技有限公司	15076683720	klq@cw-bio.com	中国	3500	55
上海宏叶生物科技有限公司	400-9205774	sales@glpbio.cn	中国	6870	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24017	58
江苏艾康生物医药研发有限公司	18626450290	yftan@aikonchem.com	中国	10718	58

94345-47-8, 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide 相关搜索:

4,4'-(庚烷-1,7-二基双(氧基))二苯甲脒
化合物 T11553L
94345-47-8
Benzenecarboximidamide, 4,4'-[1,7-heptanediylbis(oxy)]bis-
SBi4211
Heptamidine
4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide