I-OME-AG 538
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- CAS号:
- 1094048-77-7
- 英文名:
- I-OME-AG 538
- 英文别名:
- I-OME-AG 538;TYRPHOSTIN I-OME-AG 538;I-OME-TYRPHOSTIN AG 538;IOMeTyrphostin AG 538,I OMe Tyrphostin AG 538;α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone;ALPHA-CYANO-(3-METHOXY-4-HYDROXY-5-IODOCINNAMOYL)-(3',4'-DIHYDROXYPHENYL)KETONE;I-OMe-AG 538, α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3μ,4μ-dihydroxyphenyl)ketone
- 中文名:
- I-OME-AG 538
- 中文别名:
- 化合物 T11593
- CBNumber:
- CB8745046
- 分子式:
- C17H12INO5
- 分子量:
- 437.19
- MOL File:
- Mol file
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I-OME-AG 538化学性质
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储存条件:
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-20°C
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溶解度:
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DMSO : 50 mg/mL (114.37 mM; Need ultrasonic)
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形态:
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solid
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I-OME-AG 538性质、用途与生产工艺
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) 是 IGF-1R 激酶的特异性抑制剂。I-OMe-Tyrphostin AG 538 抑制 IGF-1R 介导的信号传导，并优先对营养缺乏的 PANC1 细胞产生细胞毒性。I-OMe-Tyrphostin AG 538 是具有 ATP 竞争性的 PI5P4Kα抑制剂，IC50 为 1 μM。
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium.
I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk.
Cell Viability Assay
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Cell Line:
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PANC-1 cells
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Concentration:
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0.1, 1, 10, 1000 µM
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Incubation Time:
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24 hours
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Result:
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Cytotoxic to PANC-1 cells in nutrient-deprived medium.
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Western Blot Analysis
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Cell Line:
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PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min)
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Concentration:
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0.03, 0.3, 3 µM
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Incubation Time:
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1 hour
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Result:
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Blocked phosphorylation of IGF-1R, Akt and Erk.
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I-OME-AG 538
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135680 | I-OMe-Tyrphostin AG 538 | | 1 mg | 681元 |
| 2024/04/30 | HY-135680 | I-OME-AG 538
I-OMe-Tyrphostin AG 538 | 1094048-77-7 | 5mg | 1500元 |
1094048-77-7, I-OME-AG 538 相关搜索:
- Kinase/Phosphatase Biology
- Receptor Tyrosine Kinase Inhibitors
- Insulin Receptor (IR)
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- C17H12INO5
- 化合物 T11593
- 1094048-77-7
- IOMeTyrphostin AG 538,I OMe Tyrphostin AG 538
- α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone
- I-OMe-AG 538, α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3μ,4μ-dihydroxyphenyl)ketone
- ALPHA-CYANO-(3-METHOXY-4-HYDROXY-5-IODOCINNAMOYL)-(3',4'-DIHYDROXYPHENYL)KETONE
- I-OME-TYRPHOSTIN AG 538
- I-OME-AG 538
- TYRPHOSTIN I-OME-AG 538