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盐屋霉素A

生物活性 靶点 体外研究 体内研究

盐屋霉素A, 12656-09-6, 结构式
盐屋霉素A
CAS号:
12656-09-6
英文名:
siomycin A
英文别名:
siomycin A;Salomycin A;Mutabilycin;Mutabillicin;Antibiotic 6741-21;AKFVOKPQHFBYCA-OFENGFFDSA-N;Mutabilycin, SporangioMycin, 6741-21, Mutabillicin;Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...
中文名:
盐屋霉素A
中文别名:
盐霉素 A;盐屋霉素A
CBNumber:
CB91371285
分子式:
C71H81N19O18S5
分子量:
1648.84
MOL File:
12656-09-6.mol

盐屋霉素A化学性质

密度:
1.65±0.1 g/cm3(Predicted)
储存条件:
-20°C
溶解度:
DMSO: complete10 mg/ml, clear, colorless to faintly yellow
形态:
White solid.
酸度系数(pKa):
10.43±0.46(Predicted)
安全信息
WGK Germany: 3

盐屋霉素A性质、用途与生产工艺

生物活性

Siomycin A 是一种硫肽抗生素，也是一种 Forkhead box M1(FOXM1) 选择性抑制剂，而且不影响 Forkhead box 家族其他成员。Siomycin A 具有抗肿瘤作用并促进细胞凋亡。

靶点

Forkhead box M1(FOXM1)

体外研究

Siomycin A (0-10 µM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells) treatment markedly reduces cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells. Among the three cell lines, the IC 50 of the human leukemia K562 cells is the lowest at 6.25 µM at 24 h, while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 µM. However, the IC 50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 µM, respectively.
Siomycin A (0-10 µM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells.
Siomycin A (0-10 µM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells.

Cell Viability Assay

Cell Line: K562, MCF7 and MiaPaCa-2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM
Incubation Time: 24, 48 and 72 hours
Result: Cell viability was markedly reduced in a dose-dependent and a time-dependent association.

Apoptosis Analysis

Cell Line: MiaPaCa-2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM
Incubation Time:
Result: Promoted apoptosis of MiaPaCa-2 cells.

Western Blot Analysis

Cell Line: MiaPaCa-2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM
Incubation Time: 24 hours
Result: The expression levels of MMP-2 and MMP-9 protein in the MiaPaCa-2 cells were significantly reduced in the 2.5, 5 and 10 µM groups.

体内研究

Siomycin A (1 µM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth in an in vivo mouse model.

Animal Model: Four- to five-week old male Balb/c nude mice with IOMM-LEE cells
Dosage: 1 µM-pretreated IOMM-Lee cells
Administration: Subcutaneous injection; for 4 weeks
Result: Decreased tumour growth in an in vivo mouse model.

盐屋霉素A 上下游产品信息

上游原料

下游产品

盐屋霉素A 生产厂家

全球有 45家供应商   盐屋霉素A国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海阿拉丁生化科技股份有限公司 18521735133 18521732826 market@aladdin-e.com 中国 25014 65
上海一飞生物科技有限公司 021-65675885 18964387627 info@efebio.com 中国 9709 58
北京普西唐生物科技有限公司 010-60605840 18892239720 psaitong@jm-bio.com 中国 12308 58
西安莱茵生物科技有限公司 86-(0)29-85992781 17792393971 info@lynnchem.com 中国 4587 58
Novachemistry 44-20819178-90 02081917890 info@novachemistry.com 英国 4381 58
上海宏叶生物科技有限公司 400-9205774 sales@glpbio.cn 中国 6870 58
深圳聚合生化科技有限公司 +86-400-002-6226 13028896684 sales@rrkchem.com 中国 55954 58
范德(北京)生物科技有限责任公司 15911056312 liming@bio-fount.com 中国 9730 58
BOC Sciences 16314854226; +16314854226 inquiry@bocsci.com 美国 19743 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
Alfa Chemistry +1-5166625404 Info@alfa-chemistry.com 美国 21317 58
杭州华飞化工有限公司 0571-85134551 18958018566 info@afinechem.com 中国 15377 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
孟成科技（上海）有限公司 400-820-6829 sales@mitachieve.com 中国 8864 58
浙江珲达生物科技有限公司 0571-89903882 13626641628 jiangnan@huidabiotech.com 中国 3659 58
MedBio脉铂医药 021-69568360 18916172912 order@med-bio.cn 中国 8141 58
安耐吉化学&3A（安徽泽升科技有限公司） 021-58432009 400-005-6266 marketing@energy-chemical.com 中国 44941 58
天津普西唐生物医药科技有限公司 010-60605840 psaitong@jm-bio.com 中国 29778 58
上海优宁维生物科技股份有限公司 18768175414 gaojun@univ-bio.com 中国 24998 58
浙江珲达生物科技有限公司 0571-0571-89903882 15990081639 sunshixuan@huidabiotech.com 中国 3705 58
南京世洲生物科技有限公司 025-85560043 15850508050 cindy.huang@synzest.com 中国 12007 58
杭州珲益生物科技有限公司 0571-89918262 13357170655 chenlingwei@hizyme.com 中国 587 58
TargetMol中国（陶术生物） 15002134094 marketing@targetmol.com 中国 24246 58
Aladdin Scientific Corporation +1-833-552-7181 sales@aladdinsci.com 美国 57511 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +86-19164747840 +86-13119157289 13119157289@163.com 中国 2971 58
杭州摩库生物医药科技有限公司 +86-057181025280; +8617767106207 sales@molcore.com 中国 49739 58
 

12656-09-6, 盐屋霉素A 相关搜索:

克林霉素 乙酰螺旋霉素 青霉素 庆大霉素 克拉霉素 阿奇霉素
  • 生化试剂
  • 微生物代谢物
  • C71H81N19O18S5
  • 盐霉素 A
  • 盐屋霉素A
  • 12656-09-6
  • Salomycin A
  • Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...
  • AKFVOKPQHFBYCA-OFENGFFDSA-N
  • Mutabilycin, SporangioMycin, 6741-21, Mutabillicin
  • siomycin A
  • Mutabilycin
  • Mutabillicin
  • Antibiotic 6741-21
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