globomycin
|
|
|
- CAS号:
- 67076-74-8
- 英文名:
- globomycin
- 英文别名:
- SF 1902;SF-1902A1;globomycin;Antibiotic SF-1902A1;Globomycin from Streptomyces hagronensis;Cyclo[Gly-[(2R,3R)-3-hydroxy*-2-methyl-1-oxononyl]-N-methyl-L-Leu-L-aIle-L-Ser-L-aThr-];Cyclo[L-alloisoleucyl-L-seryl-L-allothreonylglycyl-(2R,3R)-3-hydroxy-2-methylnonanoyl-N-methyl-L-leucyl];Glycine, N-(N-(N-(N-(N-(3-hydroxy-2-methyl-1-oxononyl)-N-methylleucyl)-L-alloisoleucyl)-L-seryl)-L-allothreonyl)-, rho-lactone
- 中文名:
- globomycin
- 中文别名:
- CBNumber:
- CB91399227
- 分子式:
- C32H57N5O9
- 分子量:
- 655.828
- MOL File:
- 67076-74-8.mol
|
|
|
globomycin化学性质
-
熔点:
-
105-108 °C
-
|
-
沸点:
-
987.8±65.0 °C(Predicted)
-
|
-
密度:
-
1.062±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
DMSO: soluble1mg/mL
-
|
-
酸度系数(pKa):
-
12.79±0.70(Predicted)
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white
-
|
globomycin性质、用途与生产工艺
Globomycin 是一种脂肽抗生素，也是一种信号肽酶 II ( LspA) 抑制剂。Globomycin 通过不可逆地结合肽酶来抑制原脂蛋白的加工。Globomycin 对 Spiroplasma melliferum 有毒性，其 MIC 在 6.25-12.5 μM 范围内。
Signal peptidase II (LspA)
Gram-negative/Gram-positive bacteria
Globomycin is capable of inhibiting the growth of S. melliferum. The MICs are 6.25 µM (4.1 µg/mL) for strain BC3 and 12.5 µM (8.2 µg/mL) for strain B88.
Globomycin can interfere with the processing of bacterial lipoproteins by inhibition of signal peptidase II in gracilicutes (Gram-negative eubacteria) and firmicutes (Gram-positive eubacteria).
In
B. diminuta
DS010 cells, in the Globomycin-treated cultures most of the organophosphate hydrolase (OPH) accumulates in the cytoplasmic fraction in an unprocessed form. This is in contrast with the untreated cells where very little precursor was detectable. Moreover, there is substantially less mature OPH detectable in the membrane fraction following Globomycin treatment. The OPH signal peptide contains an invariant cysteine residue at the junction of the signal peptidase (Spase) cleavage site along with a well conserved lipobox motif. Substitution of the conserved lipobox cysteine to serine resulted in release of OPH into the periplasm, confirming that OPH is a lipoprotein.
globomycin
上下游产品信息
上游原料
下游产品
67076-74-8, globomycin 相关搜索:
- 环肽
- C32H57N5O9
- 67076-74-8
- Cyclo[L-alloisoleucyl-L-seryl-L-allothreonylglycyl-(2R,3R)-3-hydroxy-2-methylnonanoyl-N-methyl-L-leucyl]
- SF 1902
- Glycine, N-(N-(N-(N-(N-(3-hydroxy-2-methyl-1-oxononyl)-N-methylleucyl)-L-alloisoleucyl)-L-seryl)-L-allothreonyl)-, rho-lactone
- Globomycin from Streptomyces hagronensis
- SF-1902A1
- Cyclo[Gly-[(2R,3R)-3-hydroxy*-2-methyl-1-oxononyl]-N-methyl-L-Leu-L-aIle-L-Ser-L-aThr-]
- Antibiotic SF-1902A1
- globomycin