447410-57-3
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- CAS号:
- 447410-57-3
- 英文名:
- SB-756050
- 英文别名:
- SB-756050;SB-756050, >98%;SB756050;SB 756050;SB-756050;1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane;1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-;G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19
- 中文名:
- 447410-57-3
- 中文别名:
- 化合物SB756050;1,4-双((3,4-二甲氧基苯基)磺酰基)-1,4-二氮杂环庚烷
- CBNumber:
- CB93162605
- 分子式:
- C21H28N2O8S2
- 分子量:
- 500.59
- MOL File:
- 447410-57-3.mol
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447410-57-3化学性质
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沸点:
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653.1±65.0 °C(Predicted)
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密度:
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1.328±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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-6.97±0.20(Predicted)
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447410-57-3性质、用途与生产工艺
SB-756050是选择性TGR5激动剂，对人源TGR5的EC50值为1.3 μM。
TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D).
SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different.
447410-57-3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-102016 | SB756050 | | 5 mg | 350元 |
| 2024/04/30 | HY-102016 | 447410-57-3
SB756050 | 447410-57-3 | 10mM * 1mLin DMSO | 385元 |
447410-57-3, 447410-57-3 相关搜索:
- 药靶配体
- 1,4-双((3,4-二甲氧基苯基)磺酰基)-1,4-二氮杂环庚烷
- 化合物SB756050
- 447410-57-3
- G protein-coupled Bile Acid Receptor 1,inhibit,TGR5,Inhibitor,SB756050,GPBAR1,G-protein coupled receptor 19,GPCR19
- 1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-
- SB-756050, >98%
- SB756050;SB 756050;SB-756050
- 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane
- SB-756050