158205-05-1
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- CAS号:
- 158205-05-1
- 英文名:
- L-745337
- 英文别名:
- L-745337;Thioflosulide;Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]-
- 中文名:
- 158205-05-1
- 中文别名:
- 化合物 T15687
- CBNumber:
- CB93175548
- 分子式:
- C16H13F2NO3S2
- 分子量:
- 369.41
- MOL File:
- 158205-05-1.mol
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158205-05-1化学性质
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沸点:
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495.8±55.0 °C(Predicted)
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密度:
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1.52±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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6?+-.0.20(Predicted)
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158205-05-1性质、用途与生产工艺
Thioflosulide (L-745337) 是一种选择性的 COX2 抑制剂，IC50 值为 2.3 nM，具有抗炎功效。
In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats.
158205-05-1
上下游产品信息
上游原料
下游产品
158205-05-1, 158205-05-1 相关搜索:
- 化合物 T15687
- 158205-05-1
- Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]-
- Thioflosulide
- L-745337