化合物SGN-2FF
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- CAS号:
- 2089647-47-0
- 英文名:
- SGN-2FF
- 英文别名:
- SGN-2FF;2-fluorofucose( SGN-2FF);SGN-2FF,SGN 2FF,inhibit,SGN2FF,Inhibitor
- 中文名:
- 化合物SGN-2FF
- 中文别名:
- 化合物SGN-2FF;(3S,4R,5S,6S)-3-氟-6-甲基四氢-2H-吡喃-2,4,5-三醇
- CBNumber:
- CB94668506
- 分子式:
- C6H11FO4
- 分子量:
- 166.15
- MOL File:
- 2089647-47-0.mol
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化合物SGN-2FF化学性质
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沸点:
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323.7±42.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C,protect from light
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酸度系数(pKa):
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11?+-.0.70(Predicted)
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水溶解性:
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Water : 36.67 mg/mL (220.70 mM)
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化合物SGN-2FF性质、用途与生产工艺
SGN-2FF 是一种有效的，具有口服活性的岩藻糖基化抑制剂，抑制岩藻糖基转移酶 (fucosyltransferase) 的活性，具有抗肿瘤活性。
SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.
SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.
化合物SGN-2FF
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-107366 | 化合物SGN-2FF
SGN-2FF | 2089647-47-0 | 5mg | 1500元 |
| 2024/04/30 | HY-107366 | 化合物SGN-2FF
SGN-2FF | 2089647-47-0 | 10mM * 1mLin Water | 3133元 |
2089647-47-0, 化合物SGN-2FF 相关搜索:
- 药靶配体
- (3S,4R,5S,6S)-3-氟-6-甲基四氢-2H-吡喃-2,4,5-三醇
- 化合物SGN-2FF
- 2089647-47-0
- SGN-2FF,SGN 2FF,inhibit,SGN2FF,Inhibitor
- 2-fluorofucose( SGN-2FF)
- SGN-2FF