1202710-57-3
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- CAS号:
- 1202710-57-3
- 英文名:
- GSTO-IN-2
- 英文别名:
- GSTO-IN-2;GSTO inhibitor 2;GSTOIN2,GSTO IN 2;L-Aspartic acid, L-γ-glutamyl-, 21-[(3α,5β)-23-carboxy-24-norcholan-3-yl] ester
- 中文名:
- 1202710-57-3
- 中文别名:
- 化合物 T11504
- CBNumber:
- CB94796656
- 分子式:
- C33H52N2O9
- 分子量:
- 620.78
- MOL File:
- 1202710-57-3.mol
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1202710-57-3化学性质
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沸点:
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821.7±65.0 °C(Predicted)
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密度:
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1.26±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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2.21±0.10(Predicted)
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1202710-57-3性质、用途与生产工艺
GSTO-IN-2是一种谷胱甘肽S-转移酶 (glutathione S-transferase) 抑制剂，对于GSTA2，GSTM1和GSTP1-1的 IC50 值分别为3.6，16.3，1.4 μM。
IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)
GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231..
1202710-57-3
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-112534 | GSTO-IN-2 | | 1 mg | 2200元 |
| 2024/04/30 | HY-112534 | 1202710-57-3
GSTO-IN-2 | 1202710-57-3 | 5mg | 5500元 |
1202710-57-3, 1202710-57-3 相关搜索:
- C33H52N2O9
- 化合物 T11504
- 1202710-57-3
- GSTOIN2,GSTO IN 2
- L-Aspartic acid, L-γ-glutamyl-, 21-[(3α,5β)-23-carboxy-24-norcholan-3-yl] ester
- GSTO inhibitor 2
- GSTO-IN-2