MJ33-OH lithium
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- CAS号:
- 1135306-36-3
- 英文名:
- MJ33-OH lithium
- 英文别名:
- MJ33-OH lithium
- 中文名:
- 中文别名:
- CBNumber:
- CB98054460
- 分子式:
- C22H45F3LiO7P
- 分子量:
- 516.5
- MOL File:
- 1135306-36-3.mol
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MJ33-OH lithium性质、用途与生产工艺
MJ33-OH lithium 是一种活性位点定向的、特异的、竞争性的和可逆性的磷脂酶 A2 (PLA2) 抑制剂。MJ33-OH lithium 阻断 Prdx6 的非钙依赖性磷脂酶 A2 (iPLA2) 活性。MJ33-OH lithium 对炎症性脑损伤有重要作用。
MJ33 (0.5 μM/kg; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment.
Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2.
MJ33-OH lithium
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