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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol structure

CAS No.: 128607-22-7

Chemical Name:: 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol

Synonyms: Ospemifene;CS-1039;Fc-1271a;Ccris 9205;Ospemifene >Unii-B0p231ilbk;2-(4-(4-chloro-1;Ospemifene FC-1271a;The department of pp meters;2-diphenyl-but-1-enyl)phenoxy)ethanol

CBNumber:: CB01335273

Molecular Formula:: C24H23ClO2

Molecular Weight:: 378.89

MDL Number:: MFCD00871890

MOL File:: 128607-22-7.mol

Last updated:2024-04-26 10:20:41

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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Properties

Boiling point	544.6±50.0 °C(Predicted)
Density	1.166±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	14.26±0.10(Predicted)
color	white to beige
InChIKey	LUMKNAVTFCDUIE-VHXPQNKSSA-N
CAS DataBase Reference	128607-22-7
FDA UNII	B0P231ILBK
ATC code	G03XC05

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273-P501
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HS Code	2909.49.1500

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0996	Ospemifene ≥98% (HPLC)	128607-22-7	10mg	$92.2	2024-03-01	Buy
Sigma-Aldrich	SML0996	Ospemifene ≥98% (HPLC)	128607-22-7	50mg	$300	2024-03-01	Buy
TCI Chemical	O0441	Ospemifene >98.0%(GC)	128607-22-7	100mg	$54	2024-03-01	Buy
TCI Chemical	O0441	Ospemifene >98.0%(GC)	128607-22-7	1g	$128	2024-03-01	Buy
Cayman Chemical	23755	Ospemifene ≥98%	128607-22-7	50mg	$86	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0996	10mg	$92.2	Buy
SML0996	50mg	$300	Buy
O0441	100mg	$54	Buy
O0441	1g	$128	Buy
23755	50mg	$86	Buy

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Chemical Properties,Uses,Production

Description

In February 2013, the US FDA approved ospemifene (also referred to as FC1271a), for the treatment ofmoderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy (VVA), due tomenopause. It is estimated that there are 150 million postmenopausal women worldwide with 40–70% suffering from VVA. Ospemifene is a selective estrogen receptor (ER) modulator (SERM) and the first nonhormonal, nonestrogen for the treatment of moderate to severe dyspareunia in women with menopausal VVA. It binds to ERα (IC₅₀～800 nM) and ERβ (IC₅₀～1600 nM) with tissue-specific estrogenic agonist/antagonist effects. Treatment with ospemifene increases the thickness of the vaginal tissue thereby decreasing fragility of the tissue and reducing potential for pain during sexual intercourse.

Originator

Tess Diagnostics and Pharmaceuticals/Hormos Medical/QuatRx (Finland)

Uses

Treatment of vaginal atrophy, osteoporosis, and vasomotor symptoms.

Definition

ChEBI: An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.

brand name

Osphena

Clinical Use

Ospemifene is a SERM that is currently in Phase II/III clinical trials for the treatment of postmenopausal osteoporosis and urogenital atrophy. It is a known metabolite of toremifene, a triphenylethylene derivative used to treat breast cancer.Ospemifene has been shown to have beneficial effects on the bone without significant estrogen-related side effects. The beneficial effect observed on bone stems from this agent's ability to increase osteoblast proliferation and, as a result, to enhance bone mineralization as well as bone formation. Unlike tamoxifen, ospemifene does not induce osteocyte apoptosis.

Synthesis

The drug can be synthesized succinctly in two steps. First, alkylation of commercially available 4-hydroxybenzophenone (130) with ethylene carbonate and catalytic sodium iodide in refluxing toluene provided benzophenone 131 in 94% yield. This was followed by a McMurry coupling involving benzophenone 131 with chloropropiophenone 132 in the presence of zinc powder and titanium tetrachloride in 2-methyltetrahydrofuran. This reaction gave rise to a mixture of triphenylethylenes directly as a 5.5:1 ratio of Z to E isomers which could be separated by crystallization in aqueous methanol to give a mixture of olefins, 98% of which was comprised of the desired Z-isomer corresponding to ospemifene (XVII). The product purity was further improved by recrystallization to give 99.9% of the Z-isomer in 46% yield from 131. Thus, ospemifene was synthesized in two steps and 43% overall yield.

Synthesis_128607-22-7

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Suppliers

Global( 155)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39916	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27644	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15396	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9329	58

Supplier	Advantage
Shanghai Yingrui Biopharma Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58

View Lastest Price from 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-27	Ospemifene 128607-22-7	US $6300.00 / Kg	1Kg	99	500 Kg	R&D Scientific Inc.
2021-07-13	Ospemifene 128607-22-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Ospemifene 128607-22-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Ospemifene
128607-22-7
US $6300.00 / Kg
99
R&D Scientific Inc.

Ospemifene
128607-22-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Ospemifene
128607-22-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Spectrum

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol(128607-22-7)¹HNMR

128607-22-7(2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol)Related Search:

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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol Ccris 9205 Fc-1271a Unii-B0p231ilbk Z-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol 2-(4-(4-chloro-1 2-diphenyl-but-1-enyl)phenoxy)ethanol Ospemifene FC-1271a Ethanol,2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]- CS-1039 Ospemifene > 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol USP/EP/BP Ospemifene D4Q: What is Ospemifene D4 Q: What is the CAS Number of Ospemifene D4 Q: What is the storage condition of Ospemifene D4 Q: What are the applications of Ospemifene D4 Ospemifene The department of pp meters 128607-22-7 Inhibitors