MLS-573151
- CAS No.
- 10179-57-4
- Chemical Name:
- MLS-573151
- Synonyms
- MLS-573151;4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-;MLS-573151,granulocytes,Inhibitor,Ras,inhibit,MLS-000573151,MLS 000573151,GTPase,MLS 573151,Cdc42,MLS573151,MLS000573151
- CBNumber:
- CB03152689
- Molecular Formula:
- C21H19N3O2S
- Molecular Weight:
- 377.46
- MDL Number:
- MOL File:
- 10179-57-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
MLS-573151 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15269 | MLS-573151 ≥98% | 10179-57-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15269 | MLS-573151 ≥98% | 10179-57-4 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 15269 | MLS-573151 ≥98% | 10179-57-4 | 10mg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 15269 | MLS-573151 ≥98% | 10179-57-4 | 25mg | $426 | 2024-03-01 | Buy |
| ApexBio Technology | C4738 | MLS-573151 | 10179-57-4 | 25mg | $485 | 2021-12-16 | Buy |
MLS-573151 Chemical Properties,Uses,Production
Description
The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-
Uses
The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.[Cayman Chemical]
in vitro
mls-573151 was a specific, cell permeable inhibitor of cdc42 with an ic50 of 2 μm [1]. mls-573151 showed no effect on other gtpases, including the related rho family members rhoa, rac1, and rac2. mls-573151 functioned by blocking the binding of gtp to cdc42 [1]. in marrow-derived mesenchymal stem cells, mls-573151 showed no effect on cell migration [3].
References
1) Surviladze et al. (2010), Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay; J. Biomol. Screening, 15 10 2) Wang et al. (2017), Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury; J. Cell Physiol., 232 110
MLS-573151 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 884 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |